CARD10 and KLHL12

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CARD10	KLHL12
Gene Name		caspase recruitment domain family, member 10	kelch-like family member 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm CBM Complex	Golgi Membrane Cytosol ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Receptor Signaling Complex Scaffold Activity	Protein Binding
	Biological Process	Protein Complex Assembly Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Apoptotic Process	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Optic disc parameters ( 21307088)
Protein-Protein Interactions		4 interactors: ATXN7 BCL10 IKBKG KLHL12	39 interactors: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CUL3 DGCR6 DRD4 DVL3 FGD2 FLNA GLYCTK INMT KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 NDC80 PDGFRB PEF1 PRR13 RIT1 RPP25L SDCBP SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 WDYHV1 ZBP1
Entrez ID		29775	59349
HPRD ID		06233	13925
Ensembl ID		ENSG00000100065	ENSG00000117153
Uniprot IDs		Q8NC81 Q9BWT7	Q53G59
PDB IDs			2VPJ
Enriched GO Terms of Interacting Partners?		Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Signaling Positive Regulation Of Mast Cell Cytokine Production Lymphotoxin A Biosynthetic Process Interleukin-6 Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Negative Regulation Of Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mature B Cell Apoptotic Process Regulation Of Innate Immune Response Regulation Of Phosphorylation Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Interleukin-6 Production Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Establishment Of Organelle Localization Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Cytokine Production B Cell Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Apoptotic Process Organelle Localization Regulation Of Interleukin-8 Biosynthetic Process Immune Response-regulating Signaling Pathway T Cell Apoptotic Process Regulation Of Cytokine Production Regulation Of B Cell Apoptotic Process Histone Deubiquitination COPII Vesicle Coating Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway COPII-coated Vesicle Budding	Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Component Assembly Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Kinase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Kinase Activity Coronary Vasculature Development Actin Cytoskeleton Organization Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Chromosome Segregation Actin Filament-based Process Positive Regulation Of Catalytic Activity Anatomical Structure Development Cellular Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Modification-dependent Protein Catabolic Process Cell Projection Assembly Regulation Of MAP Kinase Activity Positive Regulation Of Cell Division Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Chemotaxis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division
Tagcloud ?		100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Difference) ?		100nm 24h 26s 4t1 avenues bortezomib controversial dffb entirely folding grp78 ingenuity ipa label lc modulated myeloma noxa nucleic proteasomal proteasome proteolytic psmd14 puma sequestosome tceb2 top traf3 trp53bp2
Tagcloud (Intersection) ?