CARD10 and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 29467281)
59

Data Source:
BioGRID (two hybrid)

		CARD10	GIPC1
Description		caspase recruitment domain family member 10	GIPC PDZ domain containing family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm CBM Complex	Cytoplasm Cytosol Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding Signaling Receptor Complex Adaptor Activity	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding Identical Protein Binding Cadherin Binding
	Biological Process	Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Immune Response Protein-containing Complex Assembly Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Localization To Nucleus	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways			FGFR1b ligand binding and activation FGFR1c ligand binding and activation TGFBR3 regulates TGF-beta signaling TGFBR3 regulates FGF2 signaling
Drugs
Diseases
GWAS		Autoimmune hepatitis type-1 ( 24768677) Low vWF levels ( 26486471) Optic disc area ( 21307088 25631615 28073927 31798171) Optic disc size ( 31809533) Refractive error ( 32231278) Vertical cup-disc ratio ( 25241763 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Femur bone mineral density x serum urate levels interaction ( 34046847) Kidney stones ( 31729369)
Interacting Genes		105 interacting genes: ATXN7 BAHD1 BCL10 BCL6B C8orf48 CARD9 CATSPER1 CBX8 CCDC116 CCDC187 CDC37 CEP95 CHIC2 CNNM3 CWF19L2 CXCL16 CYSRT1 DHX57 DOCK2 DRC4 DUSP26 FAM47B FOXD4L3 GADD45GIP1 GFAP GIPC1 GPATCH2L GSE1 GSTP1 HBZ HOXB9 IKBKG IL16 JOSD1 KANK2 KDM1A KEAP1 KLHL12 KRT75 KRTAP10-8 KRTAP12-3 KRTAP26-1 KRTAP9-2 KRTAP9-3 LENG1 MAGOHB METTL17 MITD1 MYPOP NME7 OLIG3 PIBF1 PKP1 PNKP PRDM14 PRPF18 PRPF3 PRR35 PTCD1 PTGDS RIN1 SCNM1 SEMA3B SPATA18 SPMIP2 TBC1D22B TBC1D26 TFAP2D TMEM43 TRIM27 TRIM41 USP54 UTP14C ZBTB26 ZFP1 ZNF10 ZNF12 ZNF165 ZNF180 ZNF202 ZNF223 ZNF239 ZNF250 ZNF285 ZNF286A ZNF32 ZNF329 ZNF366 ZNF414 ZNF415 ZNF439 ZNF440 ZNF524 ZNF552 ZNF559 ZNF564 ZNF575 ZNF581 ZNF587 ZNF613 ZNF670 ZNF775 ZNF80 ZNF837 ZSCAN25	37 interacting genes: ACTN1 ADRB1 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KCNJ6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 PLEKHA2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SLC2A1 TGFBR3 TPBG TYRP1 VANGL2 ZFPM1 ZNF408
Entrez ID		29775	10755
HPRD ID		06233	05462
Ensembl ID		ENSG00000100065	ENSG00000123159
Uniprot IDs		Q9BWT7	A8K2I7 O14908
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process DNA Binding Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Protein Binding Regulation Of Metabolic Process Nucleus Intermediate Filament Metal Ion Binding DNA-binding Transcription Factor Activity Keratin Filament RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Identical Protein Binding CBM Complex	Plasma Membrane Glutamatergic Synapse Membrane Cell Migration Regulation Of Locomotion Regulation Of Signal Transduction Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Migration Receptor Complex Positive Regulation Of Signal Transduction Axon Regulation Of Cell Motility Cell Motility PDZ Domain Binding Cell Projection Organization Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Surface Anatomical Structure Formation Involved In Morphogenesis Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Nervous System Development Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Regulation Of Nervous System Development Positive Regulation Of Cellular Component Organization Endocytic Vesicle Positive Regulation Of Locomotion Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Apoptotic Process Neural Tube Closure Anatomical Structure Morphogenesis Regulation Of Programmed Cell Death Tube Closure Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Migration Insulin-like Growth Factor I Binding Positive Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility
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