KLHL3 and C6orf165

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KLHL3	C6orf165
Gene Name		kelch-like family member 3	chromosome 6 open reading frame 165
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: C6orf165 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 SYNCRIP SYT2 WNK3 WNK4	25 interactors: ADAMTSL4 AES APIP BANP C1orf94 CEP57L1 GFAP GLYR1 GPRASP2 GSE1 KLHL3 KRT31 KRT40 KRTAP13-1 LZTS2 MDFI RNF138 ROCK1 SAMD3 SOX30 TCF12 TFIP11 TMCC2 UBXN11 USHBP1
Entrez ID		26249	154313
HPRD ID		09011	12863
Ensembl ID		ENSG00000146021	ENSG00000272514
Uniprot IDs		Q9UH77	Q8IYR0 Q8N771
PDB IDs		4HXI
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus COPII Vesicle Coating G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger COPII-coated Vesicle Budding Regulation Of Calcium Ion Transport Vesicle Targeting, To, From Or Within Golgi Vesicle Organization Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding ER To Golgi Vesicle-mediated Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Distal Tubule Morphogenesis Trophectodermal Cellular Morphogenesis Positive Regulation Of Protein Metabolic Process Renal Sodium Ion Absorption Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport CRD-mediated MRNA Stabilization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Rubidium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Cytoplasmic Transport Signal Transduction Response To Organic Substance Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Wnt Signaling Pathway Response To Cytokine Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks
Tagcloud (Intersection) ?