KLHL3 and WNK3

Number of citations of the paper that reports this interaction (PMID 23387299)
14

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method)

		KLHL3	WNK3
Gene Name		kelch-like family member 3	WNK lysine deficient protein kinase 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Adherens Junction Tight Junction
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity
	Biological Process	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Protein Phosphorylation Positive Regulation Of Sodium Ion Transport Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Protein Autophosphorylation Positive Regulation Of Calcium Ion Transport Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity
Pathways			Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: C6orf165 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 SYNCRIP SYT2 WNK3 WNK4	1 interactors: KLHL3
Entrez ID		26249	65267
HPRD ID		09011	02289
Ensembl ID		ENSG00000146021	ENSG00000196632
Uniprot IDs		Q9UH77	Q9BYP7
PDB IDs		4HXI
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus COPII Vesicle Coating G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger COPII-coated Vesicle Budding Regulation Of Calcium Ion Transport Vesicle Targeting, To, From Or Within Golgi Vesicle Organization Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding ER To Golgi Vesicle-mediated Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Distal Tubule Morphogenesis Trophectodermal Cellular Morphogenesis Positive Regulation Of Protein Metabolic Process Renal Sodium Ion Absorption Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport CRD-mediated MRNA Stabilization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Rubidium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Cytoplasmic Transport Signal Transduction Response To Organic Substance Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Wnt Signaling Pathway Response To Cytokine Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Vesicle Localization	Distal Tubule Morphogenesis Renal Sodium Ion Absorption Renal Sodium Ion Transport Renal Absorption Distal Tubule Development Protein K48-linked Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Nephron Morphogenesis Renal Tubule Morphogenesis Renal System Process Renal Tubule Development Kidney Morphogenesis Nephron Development Kidney Epithelium Development Protein Polyubiquitination Sodium Ion Transport Kidney Development Renal System Development Epithelial Tube Morphogenesis Urogenital System Development
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks	aldosterone apparently coimmunoprecipitation cotransporter elimination f242a hek293 lacks laevis ncc nedd2 nedd4 oocytes partner phosphorylate pull py recover s222 s222a s328 s328a sgk1 spak thiazide threonine transferase ubiquitylation xenopus
Tagcloud (Difference) ?		aii cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks	aldosterone apparently coimmunoprecipitation elimination f242a hek293 lacks laevis ncc nedd2 nedd4 oocytes partner phosphorylate pull py recover s222 s222a s328 s328a sgk1 spak thiazide threonine transferase ubiquitylation xenopus
Tagcloud (Intersection) ?		cotransporter