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KLHL3 and KLHL12
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
KLHL3
KLHL12
Gene Name
kelch-like family member 3
kelch-like family member 12
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cul3-RING Ubiquitin Ligase Complex
Golgi Membrane
Cytosol
ER To Golgi Transport Vesicle
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Actin Binding
Structural Molecule Activity
Protein Binding
Protein Binding
Biological Process
Protein Ubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Ion Homeostasis
Renal Sodium Ion Absorption
Protein K48-linked Ubiquitination
Distal Tubule Morphogenesis
Protein Monoubiquitination
ER To Golgi Vesicle-mediated Transport
Wnt Signaling Pathway
COPII Vesicle Coating
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
TCF dependent signaling in response to WNT
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
degradation of DVL
Signaling by Wnt
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions
12 interactors:
C6orf165
CUL3
GNAI1
GNAO1
KEAP1
KLHL12
MORF4L2
OPRD1
SYNCRIP
SYT2
WNK3
WNK4
39 interactors:
ARAF
ATXN1
BAG6
C1QTNF2
CARD10
CCBE1
COL8A1
CPSF6
CUL3
DGCR6
DRD4
DVL3
FGD2
FLNA
GLYCTK
INMT
KLHL2
KLHL3
LNX1
MED28
MPP1
MRPL10
NDC80
PDGFRB
PEF1
PRR13
RIT1
RPP25L
SDCBP
SNX20
SYNE4
TAOK2
TBC1D10C
TTBK2
UBE2I
VEGFB
VTA1
WDYHV1
ZBP1
Entrez ID
26249
59349
HPRD ID
09011
13925
Ensembl ID
ENSG00000146021
ENSG00000117153
Uniprot IDs
Q9UH77
Q53G59
PDB IDs
4HXI
2VPJ
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cellular Response To Stimulus
COPII Vesicle Coating
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
COPII-coated Vesicle Budding
Regulation Of Calcium Ion Transport
Vesicle Targeting, To, From Or Within Golgi
Vesicle Organization
Protein Monoubiquitination
Localization Within Membrane
Vesicle Targeting
Response To Stimulus
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Rubidium Ion Transport
Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity
Positive Regulation Of Proteasomal Protein Catabolic Process
Membrane Budding
ER To Golgi Vesicle-mediated Transport
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Distal Tubule Morphogenesis
Trophectodermal Cellular Morphogenesis
Positive Regulation Of Protein Metabolic Process
Renal Sodium Ion Absorption
Proteasomal Ubiquitin-independent Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Protein Ubiquitination
Positive Regulation Of Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Pancreatic Juice Secretion
Renal Sodium Ion Transport
CRD-mediated MRNA Stabilization
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Rubidium Ion Transport
Protein Modification By Small Protein Conjugation
Regulation Of Ion Transport
Cytoplasmic Transport
Signal Transduction
Response To Organic Substance
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Wnt Signaling Pathway
Response To Cytokine
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Establishment Of Vesicle Localization
Vesicle Localization
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Regulation Of Signaling
Regulation Of Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Cellular Component Assembly
Positive Regulation Of Transferase Activity
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Anatomical Structure Morphogenesis
Positive Regulation Of Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Kinase Activity
Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Cellular Protein Metabolic Process
Regulation Of Kinase Activity
Coronary Vasculature Development
Actin Cytoskeleton Organization
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cellular Metabolic Process
Intracellular Signal Transduction
Chromosome Segregation
Actin Filament-based Process
Positive Regulation Of Catalytic Activity
Anatomical Structure Development
Cellular Protein Modification Process
Activation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Formation Involved In Morphogenesis
Modification-dependent Protein Catabolic Process
Cell Projection Assembly
Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Division
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Chemotaxis
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Mitotic Nuclear Division
Tagcloud
?
aii
cotransporter
cul3
cullin
depletion
directing
hyperkalemia
hypertension
impair
inverse
kelch
ligase
maximize
maximized
missense
nacl
obligatory
obscure
phenocopy
physiologic
posited
prevents
reabsorption
s433
salt
volume
wnk1
wnk4
wnks
Tagcloud (Difference)
?
aii
cotransporter
cul3
cullin
depletion
directing
hyperkalemia
hypertension
impair
inverse
kelch
ligase
maximize
maximized
missense
nacl
obligatory
obscure
phenocopy
physiologic
posited
prevents
reabsorption
s433
salt
volume
wnk1
wnk4
wnks
Tagcloud (Intersection)
?