KLHL3 and SYT2

Number of citations of the paper that reports this interaction (PMID 10734137)
17

Data Source:
HPRD (in vitro)

		KLHL3	SYT2
Gene Name		kelch-like family member 3	synaptotagmin II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Chromaffin Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Protein Ubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ion Homeostasis Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	Transport Pathogenesis
Pathways			Uptake and actions of bacterial toxins Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: C6orf165 CUL3 GNAI1 GNAO1 KEAP1 KLHL12 MORF4L2 OPRD1 SYNCRIP SYT2 WNK3 WNK4	5 interactors: KLHL3 NRXN1 STON2 SYNCRIP WNK1
Entrez ID		26249	127833
HPRD ID		09011	02520
Ensembl ID		ENSG00000146021	ENSG00000143858
Uniprot IDs		Q9UH77	Q8N9I0
PDB IDs		4HXI
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus COPII Vesicle Coating G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger COPII-coated Vesicle Budding Regulation Of Calcium Ion Transport Vesicle Targeting, To, From Or Within Golgi Vesicle Organization Protein Monoubiquitination Localization Within Membrane Vesicle Targeting Response To Stimulus Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rubidium Ion Transport Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity Positive Regulation Of Proteasomal Protein Catabolic Process Membrane Budding ER To Golgi Vesicle-mediated Transport Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Distal Tubule Morphogenesis Trophectodermal Cellular Morphogenesis Positive Regulation Of Protein Metabolic Process Renal Sodium Ion Absorption Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport CRD-mediated MRNA Stabilization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation Regulation Of Rubidium Ion Transport Protein Modification By Small Protein Conjugation Regulation Of Ion Transport Cytoplasmic Transport Signal Transduction Response To Organic Substance Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Wnt Signaling Pathway Response To Cytokine Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Establishment Of Vesicle Localization Vesicle Localization	Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Guanylate Kinase-associated Protein Clustering Neuroligin Clustering Gephyrin Clustering Synaptic Vesicle Clustering Distal Tubule Morphogenesis Developmental Process Vesicle Localization Renal Sodium Ion Absorption Neuronal Signal Transduction Negative Regulation Of Pancreatic Juice Secretion Renal Sodium Ion Transport N-methyl-D-aspartate Receptor Clustering Vocal Learning CRD-mediated MRNA Stabilization Negative Regulation Of Filopodium Assembly Postsynaptic Membrane Assembly Synapse Maturation Regulation Of Grooming Behavior Presynaptic Membrane Assembly Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Cell Differentiation Presynaptic Membrane Organization Auditory Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Absorption Cerebellar Granule Cell Differentiation Distal Tubule Development Organelle Localization Vocalization Behavior Prepulse Inhibition Neuron Cell-cell Adhesion Positive Regulation Of Synapse Maturation Mechanosensory Behavior Cerebellar Granular Layer Morphogenesis Response To Auditory Stimulus Regulation Of Synapse Maturation Protein Localization To Synapse System Development Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Membrane Assembly Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Cerebellar Granular Layer Development Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Membrane Biogenesis Positive Regulation Of Protein Localization To Plasma Membrane MRNA Stabilization
Tagcloud ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks	anion apical begin bring buffered ca2 chloromethylfluorescein cmfda conferring cytosolic diacetate disrupted epithelia hepatocytes inositol insp3r insp3rs mis peri polarized synaptotagmins syt1 syts tether tethered tethering tethers trisphosphate waves
Tagcloud (Difference) ?		aii cotransporter cul3 cullin depletion directing hyperkalemia hypertension impair inverse kelch ligase maximize maximized missense nacl obligatory obscure phenocopy physiologic posited prevents reabsorption s433 salt volume wnk1 wnk4 wnks	anion apical begin bring buffered ca2 chloromethylfluorescein cmfda conferring cytosolic diacetate disrupted epithelia hepatocytes inositol insp3r insp3rs mis peri polarized synaptotagmins syt1 syts tether tethered tethering tethers trisphosphate waves
Tagcloud (Intersection) ?