KLHL3 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 30718414)
55

Data Source:
BioGRID (enzymatic study)

		KLHL3	PPP3CA
Description		kelch like family member 3	protein phosphatase 3 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Gene Expression Macroautophagy Protein Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoatomic Ion Homeostasis Potassium Ion Homeostasis Renal Absorption Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Distal Tubule Morphogenesis	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Heart failure ( 31919418) Hemoglobin ( 32888494) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)	Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		16 interacting genes: AKT1 CFAP206 GNAI1 GNAO1 KLHL12 MORF4L2 OPRD1 PPP3CA PRKACA RBX1 SYNCRIP SYT2 TNPO2 UBE2D3 WNK3 WNK4	44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119
Entrez ID		26249	5530
HPRD ID		09011	00234
Ensembl ID		ENSG00000146021	ENSG00000138814
Uniprot IDs		Q9UH77	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		4CH9 4HXI 5NKP	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G
Enriched GO Terms of Interacting Partners?		Renal Sodium Ion Transport Renal Sodium Ion Absorption Renal Absorption Renal System Process Regulation Of Metal Ion Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Secretion Negative Regulation Of Protein Localization Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Postsynaptic Modulation Of Chemical Synaptic Transmission Proteasomal Protein Catabolic Process Regulation Of Transport Positive Regulation Of Steroid Biosynthetic Process Adenylate Cyclase Regulator Activity Positive Regulation Of Steroid Metabolic Process Negative Regulation Of Pancreatic Juice Secretion Ubiquitin-dependent Protein Catabolic Process Regulation Of System Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization Regulation Of Cholesterol Metabolic Process Protein Catabolic Process Negative Regulation Of Secretion Protein Monoubiquitination Sodium Ion Transport Proteolysis Involved In Protein Catabolic Process TORC1 Signaling Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Negative Regulation Of TORC1 Signaling Regulation Of Sodium Ion Transport Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Protein Localization To Cell Periphery Regulation Of Calcium Ion Transport Regulation Of Steroid Biosynthetic Process Protein Modification Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway TOR Signaling Negative Regulation Of TOR Signaling Nuclear Transport Nucleocytoplasmic Transport Vascular Endothelial Cell Response To Fluid Shear Stress Nucleotide Binding	Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process
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