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KLHL3
Gene Name
kelch-like family member 3
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytoskeleton
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
Actin Binding
Structural Molecule Activity
Protein Binding
Biological Process
Protein Ubiquitination
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Ion Homeostasis
Renal Sodium Ion Absorption
Protein K48-linked Ubiquitination
Distal Tubule Morphogenesis
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions
12 interactors:
C6orf165
CUL3
GNAI1
GNAO1
KEAP1
KLHL12
MORF4L2
OPRD1
SYNCRIP
SYT2
WNK3
WNK4
Entrez ID
26249
HPRD ID
09011
Ensembl ID
ENSG00000146021
Uniprot IDs
Q9UH77
PDB IDs
4HXI
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cellular Response To Stimulus
COPII Vesicle Coating
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
COPII-coated Vesicle Budding
Regulation Of Calcium Ion Transport
Vesicle Targeting, To, From Or Within Golgi
Vesicle Organization
Protein Monoubiquitination
Localization Within Membrane
Vesicle Targeting
Response To Stimulus
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Rubidium Ion Transport
Positive Regulation Of Rubidium Ion Transmembrane Transporter Activity
Positive Regulation Of Proteasomal Protein Catabolic Process
Membrane Budding
ER To Golgi Vesicle-mediated Transport
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Distal Tubule Morphogenesis
Trophectodermal Cellular Morphogenesis
Positive Regulation Of Protein Metabolic Process
Renal Sodium Ion Absorption
Proteasomal Ubiquitin-independent Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Protein Ubiquitination
Positive Regulation Of Metabolic Process
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of Pancreatic Juice Secretion
Renal Sodium Ion Transport
CRD-mediated MRNA Stabilization
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase By Cyclin Degradation
Regulation Of Rubidium Ion Transport
Protein Modification By Small Protein Conjugation
Regulation Of Ion Transport
Cytoplasmic Transport
Signal Transduction
Response To Organic Substance
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Wnt Signaling Pathway
Response To Cytokine
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Cellular Metabolic Process
Establishment Of Vesicle Localization
Vesicle Localization
Tagcloud
?
aii
cotransporter
cul3
cullin
depletion
directing
hyperkalemia
hypertension
impair
inverse
kelch
ligase
maximize
maximized
missense
nacl
obligatory
obscure
phenocopy
physiologic
posited
prevents
reabsorption
s433
salt
volume
wnk1
wnk4
wnks