PDE6D and GRK1

Number of citations of the paper that reports this interaction (PMID 16473576)
4

Data Source:
HPRD (in vitro, two hybrid)

		PDE6D	GRK1
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	G protein-coupled receptor kinase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Photoreceptor Disc Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	Protein Kinase Activity G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Visual Perception Phototransduction, Visible Light Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Photoreceptor Cell Morphogenesis Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Protein Autophosphorylation Post-embryonic Retina Morphogenesis In Camera-type Eye
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	8 interactors: CALM1 CAV1 PDE6D RCVRN RHO SNCA SNCB SNCG
Entrez ID		5147	6011
HPRD ID		04056	01585
Ensembl ID		ENSG00000156973
Uniprot IDs		O43924 Q6IB24	Q15835
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Ion Transport Regulation Of Oxidoreductase Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Detection Of Visible Light Positive Regulation Of Calcium Ion Transport Cellular Response To Light Stimulus Phototransduction Negative Regulation Of Ion Transport Detection Of Light Stimulus Negative Regulation Of Monooxygenase Activity Response To Abiotic Stimulus Response To Inorganic Substance Cellular Response To Radiation Regulation Of Ion Homeostasis Regulation Of Dopamine Secretion Synapse Organization Visual Perception Detection Of Abiotic Stimulus Sensory Perception Of Light Stimulus Synaptic Transmission Regulation Of Catalytic Activity Negative Regulation Of Oxidoreductase Activity Positive Regulation Of Ion Transport Dopamine Metabolic Process Nitric Oxide Metabolic Process Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Oxidoreductase Activity Negative Regulation Of Catalytic Activity Negative Regulation Of Transporter Activity Catecholamine Metabolic Process Receptor Internalization Positive Regulation Of Lyase Activity Regulation Of Signaling Negative Regulation Of Ion Transmembrane Transport Response To Cocaine Response To Organic Cyclic Compound Response To External Stimulus Negative Regulation Of Protein Phosphorylation Cell-cell Signaling Response To Metal Ion Negative Regulation Of Transmembrane Transport Response To Light Stimulus
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk2 grk4 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?