PDE6D and RHEB

Number of citations of the paper that reports this interaction (PMID 11980706)
39

Data Source:
BioGRID (two hybrid)
HPRD (in vivo, two hybrid)

		PDE6D	RHEB
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	Ras homolog enriched in brain
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Golgi Membrane Spliceosomal Complex Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Cell Cycle Arrest Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of TOR Signaling
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Insulin receptor signalling cascade IRS-mediated signalling Regulation of Rheb GTPase activity by AMPK mTOR signalling S6K1-mediated signalling IRS-related events mTOR signalling Release of eIF4E mTORC1-mediated signalling IGF1R signaling cascade S6K1-mediated signalling mTORC1-mediated signalling IRS-related events triggered by IGF1R IRS-mediated signalling Release of eIF4E Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	22 interactors: A2M APOE ARIH2 ATM ATR BNIP3 BNIP3L BRAF ECSIT FKBP8 MTOR NCAM1 PDE6D PLD1 PSEN1 PSEN2 RABAC1 RAF1 RPS6KB1 RPTOR TSC1 TSC2
Entrez ID		5147	6009
HPRD ID		04056	03188
Ensembl ID		ENSG00000156973	ENSG00000106615
Uniprot IDs		O43924 Q6IB24	Q15382
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF	1XTQ 1XTR 1XTS 3SEA 3T5G
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Intracellular Signal Transduction Signal Transduction Signaling Cell Communication Regulation Of Signal Transduction Response To Stress Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Response To Peptide Hormone Insulin Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Protein Metabolic Process Response To Insulin Response To Peptide Cell Differentiation Regulation Of Protein Kinase Activity Response To External Stimulus Response To Stimulus Regulation Of Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Response To Heat Cellular Response To Insulin Stimulus Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Apoptotic Process Developmental Process Positive Regulation Of Signal Transduction Negative Regulation Of Programmed Cell Death Immune System Process Response To Heat Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Death Cell Development Regulation Of Cell Size Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Response To Hypoxia Regulation Of Cellular Component Organization Regulation Of Cell Death Cellular Response To Peptide Hormone Stimulus Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Negative Regulation Of Cell Size Cellular Response To Peptide Cellular Response To Heat Cellular Response To Growth Factor Stimulus Neural Tube Development
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	abovementioned altogether amls angiomyolipomas carry chronically comparative deficient diminished farnesylthiosalicylic fts indeed irf7 lam lymphangioleiomyomatosis mimicked mtorc1 neoplasms pathologies phenomena rapamycin salirasib sirolimus sporadic trans tsc tsc2 tuberous yielded
Tagcloud (Intersection) ?