PDE6D and ARL3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		PDE6D	ARL3
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	ADP-ribosylation factor-like 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Golgi Membrane Nucleus Golgi Apparatus Centrosome Spindle Microtubule Cytoplasmic Microtubule Midbody Photoreceptor Connecting Cilium Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding Microtubule Binding GDP Binding Metal Ion Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Cytokinesis Kidney Development Post-Golgi Vesicle-mediated Transport Organelle Organization Smoothened Signaling Pathway Small GTPase Mediated Signal Transduction Protein Transport Intraciliary Transport Photoreceptor Cell Development Cilium Morphogenesis
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Trafficking of myristoylated proteins to the cilium Assembly of the primary cilium
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Prostate cancer ( 23535732)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	10 interactors: ARL2BP GOLGA4 LRIF1 PDE6D RP2 TLE1 TP53 TUBA1A UBR1 UNC119
Entrez ID		5147	403
HPRD ID		04056	05260
Ensembl ID		ENSG00000156973	ENSG00000138175
Uniprot IDs		O43924 Q6IB24	P36405
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Positive Regulation Of Peptidyl-tyrosine Phosphorylation Visual Perception Sensory Perception Of Light Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Clathrin-mediated Endocytosis Regulation Of Cellular Amino Acid Metabolic Process Protein Localization Post-Golgi Vesicle-mediated Transport Negative Regulation Of Macromitophagy Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Oligodendrocyte Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Protein Localization To Organelle Cytokinesis, Completion Of Separation Negative Regulation Of Helicase Activity Notch Signaling Pathway Regulation Of Catalytic Activity Cellular Localization Protein Transport Protein Localization To Nucleus Establishment Of Protein Localization Mitotic Cell Cycle Process Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of Cell Aging Intracellular Transport Mitochondrial DNA Repair Response To Leucine Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Mitotic Cell Cycle Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Mitotic Cytokinetic Process Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Sensory Perception Regulation Of Intracellular Signal Transduction ER Overload Response Positive Regulation Of Phosphorylation Negative Regulation Of Macroautophagy Stress-induced Premature Senescence
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian transporter trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	accord brucei congolense conservation cruzi donovani eukaryotes flanking genesis leishmania monophyly multigene organization parasites phylogeny primitive protozoan rab1 reconstitution representatives s12 salivarian transporter trypanosoma trypanosomatids trypanosomes unicellular vivax ypt6
Tagcloud (Intersection) ?