PDE6D and RAB8A

Number of citations of the paper that reports this interaction (PubMedID 16473576)
0

Data Source:
HPRD (two hybrid)

		PDE6D	RAB8A
Description		phosphodiesterase 6D	RAB8A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosome Endosome Golgi Apparatus Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Cilium Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Membrane Trans-Golgi Network Transport Vesicle Dendrite Midbody Phagocytic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Centriolar Satellite Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Ciliary Base Non-motile Cilium Glutamatergic Synapse
	Molecular Function	GTPase Inhibitor Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Kinase Binding Small GTPase Binding Myosin V Binding Protein Tyrosine Kinase Binding
	Biological Process	Visual Perception Sensory Perception Of Light Stimulus	Exocytosis Vesicle Docking Involved In Exocytosis Autophagy Golgi Organization Axonogenesis Regulation Of Autophagy Protein Transport Cell Projection Organization Endocytic Recycling Cellular Response To Insulin Stimulus Regulation Of Protein Localization Regulation Of Long-term Neuronal Synaptic Plasticity Golgi Vesicle Fusion To Target Membrane Regulation Of Protein Transport Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RAS processing	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Anchoring of the basal body to the plasma membrane VxPx cargo-targeting to cilium TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252) Mean platelet volume ( 27863252 32888494) Platelet count ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	23 interacting genes: BAG6 BIRC6 GDI2 IKBKG MAP4K2 MDM2 MYO5C OCRL ODF2 OPTN PDE6D PQBP1 RAB11A RAB13 RAB3IL1 RAB3IP RABIF RIMS2 RPH3A RPH3AL SYTL1 SYTL4 TFRC
Entrez ID		5147	4218
HPRD ID		04056	01296
Ensembl ID		ENSG00000156973	ENSG00000167461
Uniprot IDs		B8ZZK5 O43924 Q6IB24	P61006
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW 7PAC 7PAD 7PAE 7Q9Q 7Q9R 7Q9S 7Q9U 7QF9 7QJK	3QBT 3TNF 4LHV 4LHW 4LHX 4LHY 4LHZ 4LI0 5SZI 6RIR 6SQ2 6STF 6STG 6WHE 6YX5 6ZSI 6ZSJ 7BWT 7LWB 9IKQ
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding GDP Binding Nucleotide Binding Small GTPase-mediated Signal Transduction G Protein Activity Intracellular Signaling Cassette Ciliary Basal Body Intracellular Signal Transduction Mitotic Cytokinesis Midbody Rhodopsin Kinase Activity Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Centrosome Photoreceptor Connecting Cilium Hydrolase Activity Signal Transduction G Protein-coupled Receptor Kinase Activity Cellular Developmental Process Golgi Apparatus Extracellular Exosome Rap Protein Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Cilium Cell-cell Junction Organization Cytoskeleton Regulation Of Actin Cytoskeleton Organization Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process Regulation Of Modification Of Postsynaptic Structure Cellular Response To Forskolin Phagocytic Vesicle Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Response To Forskolin Trans-Golgi Network Transport Vesicle Protein Localization To Cell Periphery Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Modification Of Synaptic Structure Recycling Endosome Membrane Photoreceptor Disc Membrane Protein Kinase Binding Establishment Of Apical/basal Cell Polarity G-protein Beta/gamma-subunit Complex Binding Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Actin Filament Organization Cell Junction Assembly Establishment Or Maintenance Of Monopolar Cell Polarity	Small GTPase Binding Establishment Of Protein Localization Protein Transport Intracellular Protein Localization Vesicle-mediated Transport Post-Golgi Vesicle-mediated Transport Exocytosis Cellular Localization Cytoplasmic Vesicle Golgi To Plasma Membrane Transport Secretion By Cell Endosome Trans-Golgi Network Recycling Endosome Membrane Secretion Polyubiquitin Modification-dependent Protein Binding Spontaneous Neurotransmitter Secretion Intracellular Transport Intracellular Protein Transport Regulation Of Vesicle-mediated Transport Intracellular Signal Transduction Establishment Of Localization In Cell Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Positive Regulation Of Protein Localization Golgi Vesicle Transport Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cytosol Membrane Interleukin-2-mediated Signaling Pathway Spindle Pole Organelle Localization Calcium-dependent Activation Of Synaptic Vesicle Fusion Neurexin Family Protein Binding Signal Transduction Organelle Localization By Membrane Tethering Regulation Of Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Positive Regulation Of Exocytosis Positive Regulation Of Protein Export From Nucleus Membrane Docking Positive Regulation Of Vesicle Fusion Establishment Of Protein Localization To Membrane Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Cilium Assembly Regulation Of Cell Projection Assembly K63-linked Polyubiquitin Modification-dependent Protein Binding Establishment Of Vesicle Localization
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