PDE6D and RAB18

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PDE6D	RAB18
Description		phosphodiesterase 6D	RAB18, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Cilium Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Cell Projection	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Plasma Membrane Endomembrane System Membrane Apical Plasma Membrane Secretory Granule Membrane Cis-Golgi Network Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	GTPase Inhibitor Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Visual Perception Sensory Perception Of Light Stimulus	Eye Development Intracellular Protein Transport Small GTPase-mediated Signal Transduction Brain Development Protein Transport Lipid Droplet Organization Endoplasmic Reticulum Tubular Network Organization
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RAS processing	Neutrophil degranulation COPI-independent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Warburg micro syndrome
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)	A body shape index ( 34021172) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Childhood ear infection ( 27182965 28928442) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 28552196) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		25 interacting genes: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS OTP PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	11 interacting genes: AQP6 CHM COPS4 ELOVL4 ERRFI1 FAM107A PDE6D PPP2R1A PPP2R1B TAX1BP1 TOM1L1
Entrez ID		5147	22931
HPRD ID		04056	03731
Ensembl ID		ENSG00000156973	ENSG00000099246
Uniprot IDs		B8ZZK5 O43924 Q6IB24	B7Z4P9 Q9NP72
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF 5E80 5E8F 5F2U 5ML2 5ML3 5ML4 5ML6 5ML8 5NAL 5TAR 5TB5 5X72 5X73 5X74 5YAV 5YAW 7PAC 7PAD 7PAE 7Q9Q 7Q9R 7Q9S 7Q9U 7QF9 7QJK	1X3S
Enriched GO Terms of Interacting Partners?		GTPase Activity GTP Binding GDP Binding Nucleotide Binding Small GTPase-mediated Signal Transduction G Protein Activity Intracellular Signaling Cassette Ciliary Basal Body Intracellular Signal Transduction Mitotic Cytokinesis Midbody Rhodopsin Kinase Activity Regulation Of Cytoskeleton Organization Cytoskeleton-dependent Cytokinesis Centrosome Photoreceptor Connecting Cilium Hydrolase Activity Signal Transduction G Protein-coupled Receptor Kinase Activity Cellular Developmental Process Golgi Apparatus Extracellular Exosome Rap Protein Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Protein Localization To Cilium Cell-cell Junction Organization Cytoskeleton Regulation Of Actin Cytoskeleton Organization Endothelial Tube Morphogenesis Regulation Of Actin Filament-based Process Regulation Of Modification Of Postsynaptic Structure Cellular Response To Forskolin Phagocytic Vesicle Regulation Of Cell-substrate Adhesion Establishment Of Epithelial Cell Apical/basal Polarity Response To Forskolin Trans-Golgi Network Transport Vesicle Protein Localization To Cell Periphery Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Modification Of Synaptic Structure Recycling Endosome Membrane Photoreceptor Disc Membrane Protein Kinase Binding Establishment Of Apical/basal Cell Polarity G-protein Beta/gamma-subunit Complex Binding Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Actin Filament Organization Cell Junction Assembly Establishment Or Maintenance Of Monopolar Cell Polarity	Meiotic Sister Chromatid Cohesion, Centromeric Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Autophosphorylation Protein Phosphatase Type 2A Complex Small GTPase Binding Response To Glucocorticoid Response To Corticosteroid Nitrate Transmembrane Transporter Activity Meiotic Spindle Elongation Sister Chromatid Cohesion Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Response To Steroid Hormone Trehalose Metabolic Process Trehalose Catabolic Process Alpha,alpha-trehalase Activity
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