PDE6D and RAB13

Number of citations of the paper that reports this interaction (PMID 9712853)
9

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro, in vivo)

		PDE6D	RAB13
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	RAB13, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Cytoplasm Golgi Apparatus Trans-Golgi Network Plasma Membrane Tight Junction Lateral Plasma Membrane Lamellipodium Endocytic Vesicle Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Insulin-responsive Compartment Neuron Projection Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Intracellular Protein Transport Protein Kinase A Signaling Endosomal Transport Cortical Actin Cytoskeleton Organization Neuron Projection Development Endocytic Recycling Rab Protein Signal Transduction Cellular Response To Insulin Stimulus Endothelial Cell Chemotaxis Trans-Golgi Network To Recycling Endosome Transport Membrane Organization Tight Junction Assembly Establishment Of Protein Localization To Plasma Membrane Establishment Of Sertoli Cell Barrier Protein Localization To Cell Leading Edge
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	5 interactors: PDE6D RABGAP1L SMAD4 SMURF2 TGFBR1
Entrez ID		5147	5872
HPRD ID		04056	04053
Ensembl ID		ENSG00000156973	ENSG00000143545
Uniprot IDs		O43924 Q6IB24	P51153 Q504R6
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of SMAD Protein Import Into Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of SMAD Protein Import Into Nucleus Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Cardiac Epithelial To Mesenchymal Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neuron Fate Commitment BMP Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Protein Import Into Nucleus Response To Growth Factor Palate Development Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Mesenchymal Cell Development Mesenchymal Cell Differentiation Regulation Of Protein Localization Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Regulation Of Protein Localization To Nucleus Mesenchyme Development Regulation Of Nucleocytoplasmic Transport Heart Morphogenesis Regulation Of Signal Transduction DNA-templated Transcription, Initiation Positive Regulation Of Intracellular Transport Stem Cell Development Anterior/posterior Pattern Specification Regulation Of Binding Regulation Of Intracellular Protein Transport Endocardial Cell Differentiation Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	analyzing breakpoint cdk2 census chips database degs disks dlg4 downloaded encyclopedia featured fgfr fgfr2 gbm gse4290 homologue kegg kyoto multiforme nbpf10 neuroblastoma nras omnibus pairs pathogenetic perturbing reversal
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	analyzing breakpoint cdk2 census chips database degs disks dlg4 downloaded encyclopedia featured fgfr fgfr2 gbm gse4290 homologue kegg kyoto multiforme nbpf10 neuroblastoma nras omnibus pairs pathogenetic perturbing reversal
Tagcloud (Intersection) ?