PDE6D and ARL2

Number of citations of the paper that reports this interaction (PMID 11980706)
39

Data Source:
BioGRID (two hybrid, x-ray crystallography)
HPRD (in vitro)

		PDE6D	ARL2
Gene Name		phosphodiesterase 6D, cGMP-specific, rod, delta	ADP-ribosylation factor-like 2
Image
Gene Ontology Annotations	Cellular Component	Cytosol Cytoskeleton Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Primary Cilium	Nucleus Mitochondrial Intermembrane Space Centrosome Lateral Plasma Membrane Extracellular Vesicular Exosome Primary Cilium
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity GTPase Inhibitor Activity Protein Binding Rab GTPase Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Organelle Organization Visual Perception Metabolic Process Negative Regulation Of Catalytic Activity Response To Stimulus	Tubulin Complex Assembly Cell Cycle Small GTPase Mediated Signal Transduction Metabolic Process Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Centrosome Organization Maintenance Of Protein Location In Nucleus Tight Junction Assembly
Pathways		Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance ARL13B-mediated ciliary trafficking of INPP5E Assembly of the primary cilium	Protein folding Post-chaperonin tubulin folding pathway Orphan transporters
Drugs
Diseases
GWAS		Eating disorders (purging via substances) ( 23568457) Height ( 18391951)
Protein-Protein Interactions		24 interactors: ARL15 ARL16 ARL2 ARL3 CDC42 CETN3 FAM219A GNAI1 GRK1 GRK7 HRAS PTGIR RAB13 RAB18 RAB8A RAD23A RAP1A RAP2B RASA1 RHEB RHOA RHOB RND1 RPGR	5 interactors: ARL2BP PDE6D TBCD TBL1XR1 UNC119
Entrez ID		5147	402
HPRD ID		04056	11869
Ensembl ID		ENSG00000156973	ENSG00000213465
Uniprot IDs		O43924 Q6IB24	B4DGG0 P36404 Q53YD8
PDB IDs		1KSG 1KSH 1KSJ 3T5G 3T5I 4JHP 4JV6 4JV8 4JVB 4JVF	3DOE 3DOF
Enriched GO Terms of Interacting Partners?		Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Ras Protein Signal Transduction Signal Transduction Signaling Cellular Response To Stimulus Neuron Development Cell Communication Response To Stimulus Neuron Differentiation Blood Coagulation Hemostasis Generation Of Neurons Neurogenesis Cell Morphogenesis Cell Development Nervous System Development Regulation Of Body Fluid Levels Cell Projection Organization Cell Projection Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Wound Healing Response To Wounding Cell Cycle Cell Morphogenesis Involved In Differentiation Axonogenesis Neuron Projection Development Axon Development Platelet Activation Chemotaxis Axon Guidance Neuron Projection Morphogenesis Ephrin Receptor Signaling Pathway Cell Division Vascular Endothelial Growth Factor Receptor Signaling Pathway Cytokinesis Cell Cycle Process Protein Localization Movement Of Cell Or Subcellular Component Organelle Organization Photoreceptor Cell Development Cell Differentiation Cellular Protein Localization Response To External Stimulus Rab Protein Signal Transduction System Development Protein Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process	Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Visual Perception Sensory Perception Of Light Stimulus Cytokinesis, Completion Of Separation Regulation Of Peptidyl-tyrosine Phosphorylation Post-chaperonin Tubulin Folding Pathway Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Positive Regulation Of Metabolic Process Regulation Of Clathrin-mediated Endocytosis Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Microtubule Polymerization Regulation Of Metabolic Process Maintenance Of Protein Location In Nucleus Cell Separation After Cytokinesis Negative Regulation Of Receptor-mediated Endocytosis Lipoprotein Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Microtubule Polymerization Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Tyrosine Kinase Activity
Tagcloud ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	attributed automata charged continuously diffusion electrostatic endomembranes endosome enrichment explains fitting geometries kinetic kras mislocalized pdedelta perinuclear phospholipids pm posttranslational prenylation proto realistic recycling relies restores sequestered unloaded vesicular
Tagcloud (Difference) ?		14e4 1c4 3h1 4d2 bands bmpr1b copy e5 hybridisation losses ontology pdlim5 ptc ptcs ptma slitrk1 slitrk5 slitrk6 srm t1 taf12 tp73 transgenics trk trp73 tumourigenesis twist2 unc5c ythdf2	attributed automata charged continuously diffusion electrostatic endomembranes endosome enrichment explains fitting geometries kinetic kras mislocalized pdedelta perinuclear phospholipids pm posttranslational prenylation proto realistic recycling relies restores sequestered unloaded vesicular
Tagcloud (Intersection) ?