RAB5A and RUFY1

Number of citations of the paper that reports this interaction (PubMedID 14617813)
67

Data Source:
BioGRID (proximity labelling technology, pull down)

		RAB5A	RUFY1
Description		RAB5A, member RAS oncogene family	RUN and FYVE domain containing 1
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GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane	Cytoplasm Endosome Cytosol Membrane Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding	Protein Binding Zinc Ion Binding Lipid Binding SH3 Domain Binding Protein-macromolecule Adaptor Activity SH2 Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Endocytosis Small GTPase-mediated Signal Transduction Protein Transport Regulation Of Endocytosis Endosomal Vesicle Fusion Early Endosome To Golgi Transport
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production	Synthesis of PIPs at the plasma membrane
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)
Interacting Genes		37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1	20 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX DYNC1LI1 EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A SNCA TRIM23 TXNDC17 UTP25
Entrez ID		5868	80230
HPRD ID		01542	15282
Ensembl ID		ENSG00000144566	ENSG00000176783
Uniprot IDs		P20339	A8K7B1 Q96T51
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1	2YQM 2YW8
Enriched GO Terms of Interacting Partners?		GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection	Synaptic Vesicle Recycling Vesicle-mediated Transport Clathrin-coated Vesicle Cargo Loading, AP-3-mediated AP-3 Adaptor Complex Synaptic Vesicle Transport Vesicle-mediated Transport In Synapse Anterograde Synaptic Vesicle Transport Synaptic Vesicle Coating GDP Binding Cytoplasmic Vesicle Membrane Vesicle Cargo Loading Early Endosome Protein Transport Establishment Of Vesicle Localization Anterograde Axonal Transport Vesicle Transport Along Microtubule Establishment Of Localization In Cell Vesicle Localization Establishment Of Protein Localization Vesicle Cytoskeletal Trafficking Axon Cytoplasm Axonal Transport Intracellular Protein Localization Melanosome Assembly G Protein Activity Intracellular Protein Transport Axo-dendritic Transport Cellular Localization GTP Binding Platelet Dense Granule Organization Organelle Transport Along Microtubule Intracellular Transport Membrane Coat Post-Golgi Vesicle-mediated Transport Presynapse Vesicle Coating Organelle Localization Melanosome Organization Establishment Of Organelle Localization Pigment Granule Organization Terminal Bouton Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle Organization GTPase Activity Transport Along Microtubule Receptor-mediated Endocytosis Nucleotide Binding Secretory Granule Organization Microtubule-based Movement
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