RAB5A and TBC1D3F

Number of citations of the paper that reports this interaction (PubMedID 12612085)
60

Data Source:
HPRD (in vivo)

		RAB5A	TBC1D3F
Description		RAB5A, member RAS oncogene family	TBC1 domain family member 3F
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane	Endosome Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding	GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	Ovarian cancer ( 23535730)
Interacting Genes		37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1	4 interacting genes: CDC42 RAB5A RAC1 YWHAE
Entrez ID		5868	84218
HPRD ID		01542	09667
Ensembl ID		ENSG00000144566	ENSG00000275954
Uniprot IDs		P20339	A6NER0
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection	G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Melanosome Thioesterase Binding Regulation Of Vesicle-mediated Transport Regulation Of Transport GTP-dependent Protein Binding Regulation Of Cell Projection Assembly Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Transport Phagocytosis, Engulfment Positive Regulation Of Lamellipodium Organization Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Lamellipodium Assembly GTPase Activity Substantia Nigra Development Regulation Of Filopodium Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Membrane Invagination Positive Regulation Of Stress Fiber Assembly GTP Binding Regulation Of Lamellipodium Organization Non-canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Actin Filament Bundle Assembly Neural Nucleus Development Focal Adhesion Endocytosis Dendrite Host-mediated Perturbation Of Viral Process Cytoplasmic Ribonucleoprotein Granule Phagocytic Vesicle Modulation Of Chemical Synaptic Transmission Regulation Of Neurotransmitter Secretion Cellular Localization Regulation Of Protein Catabolic Process At Presynapse, Modulating Synaptic Transmission Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Glutamatergic Synapse Regulation Of Signaling Regulation Of Secretion By Cell Host-mediated Perturbation Of Symbiont Process Membrane Organization Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Import Into Cell
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