RAB5A and GRIK4

Number of citations of the paper that reports this interaction (PubMedID 15782196)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RAB5A	GRIK4
Description		RAB5A, member RAS oncogene family	glutamate ionotropic receptor kainate type subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Cell Projection Synapse Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding	Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Signaling Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential
Pathways		Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production	Activation of Ca-permeable Kainate Receptor
Drugs		L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate	Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)	Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193) Lateral ventricle volume ( 31530798) Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1	4 interacting genes: GRIK1 GRIK2 GRIK3 RAB5A
Entrez ID		5868	2900
HPRD ID		01542	02613
Ensembl ID		ENSG00000144566	ENSG00000149403
Uniprot IDs		P20339	A0A8D9PH79 A0A8D9UJ88 A6H8K8 B2RAP6 Q16099
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Glutamate-gated Receptor Activity Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Terminal Bouton Synaptic Transmission, Glutamatergic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Negative Regulation Of Synaptic Transmission, Glutamatergic Presynaptic Membrane Glutamate Receptor Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Postsynaptic Membrane Dendrite Cytoplasm Regulation Of Long-term Neuronal Synaptic Plasticity Signaling Receptor Activity Regulation Of Presynaptic Membrane Potential Chemical Synaptic Transmission Trans-synaptic Signaling Negative Regulation Of Synaptic Transmission Synaptic Signaling Axon Regulation Of Membrane Potential Regulation Of Neuronal Synaptic Plasticity Dendrite Cell-cell Signaling Cell Surface Receptor Signaling Pathway Signaling Cell Communication Mossy Fiber Rosette Detection Of Cold Stimulus Involved In Thermoception Extracellularly Glutamate-gated Ion Channel Activity Monoatomic Ion Transmembrane Transport Perikaryon Intracellular Signaling Cassette Regulation Of Biological Quality Monoatomic Ion Transport Synapse Protein Localization To Early Endosome Regulation Of Synaptic Plasticity Ionotropic Glutamate Receptor Complex
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