RAB5A and GRIK4

Number of citations of the paper that reports this interaction (PMID 15782196)
40

Data Source:
BioGRID (fluorescent resonance energy transfer)

		RAB5A	GRIK4
Gene Name		RAB5A, member RAS oncogene family	glutamate receptor, ionotropic, kainate 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Nucleus Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding	Extracellular-glutamate-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Transport Glutamate Receptor Signaling Pathway Synaptic Transmission Response To Corticosteroid Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic
Pathways		Factors involved in megakaryocyte development and platelet production	Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs			L-Glutamic Acid
Diseases
GWAS			Attention deficit hyperactivity disorder ( 23728934) Cognitive performance ( 20125193)
Protein-Protein Interactions		41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL	2 interactors: GRIK2 RAB5A
Entrez ID		5868	2900
HPRD ID		01542	02613
Ensembl ID		ENSG00000144566	ENSG00000149403
Uniprot IDs		B4DJA5 P20339	Q16099
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Transport Regulation Of Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Regulation Of Exocytosis Regulation Of Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Endosome Size Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Regulation Of Secretion Protein Retention In ER Lumen Regulation Of Short-term Neuronal Synaptic Plasticity Maintenance Of Protein Localization In Endoplasmic Reticulum Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Intracellular Protein Transport Early Endosome To Late Endosome Transport Regulation Of Cellular Localization Positive Regulation Of Smooth Muscle Cell Migration Neuronal Action Potential Membrane Hyperpolarization Behavioral Fear Response Regulation Of Vesicle Fusion Synaptic Vesicle Recycling Fear Response Cellular Protein Localization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Migration Protein Transport Receptor Internalization Establishment Of Protein Localization Regulation Of Filopodium Assembly Receptor Clustering Intracellular Transport Transmission Of Nerve Impulse Neuron Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Rab Protein Signal Transduction Positive Regulation Of Neuron Apoptotic Process Glutamate Receptor Signaling Pathway Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Negative Regulation Of Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	500x abl actionable alk amplifications asxl1 copy correctly coverage deep deletions duplications eml4 formalin gains guide insertions losses mixing mll oncoplex paraffin pik3r1 rearrangements ros1 sgcz underdeveloped uw validate
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	500x abl actionable alk amplifications asxl1 copy correctly coverage deep deletions duplications eml4 formalin gains guide insertions losses mixing mll oncoplex paraffin pik3r1 rearrangements ros1 sgcz underdeveloped uw validate
Tagcloud (Intersection) ?