RAB5A and RABEP1

Number of citations of the paper that reports this interaction (PMID 8521472)
123

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		RAB5A	RABEP1
Gene Name		RAB5A, member RAS oncogene family	rabaptin, RAB GTPase binding effector protein 1
Image
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Actin Cytoskeleton Endocytic Vesicle Axon Dendrite Somatodendritic Compartment Melanosome Zymogen Granule Membrane Neuronal Cell Body Terminal Bouton Protein Complex Axon Terminus Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane	Endosome Early Endosome Endocytic Vesicle Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GDP-dissociation Inhibitor Binding	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Smooth Muscle Cell Migration Regulation Of Endocytosis Rab Protein Signal Transduction Synaptic Vesicle Recycling Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Endosome Size Regulation Of Filopodium Assembly Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis	Endocytosis Apoptotic Process Protein Transport Positive Regulation Of GTPase Activity Membrane Fusion
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		41 interactors: AGTR1 ALS2CL ANKFY1 AP1G1 AP1G2 APPL1 APPL2 CHM CHML EEA1 GDI2 GGA1 GGA2 GGA3 GRIK4 ITSN1 NME2 OCRL RAB37 RAB7A RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 STX4 SUN2 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TSC2 USP6NL	22 interactors: AP1G1 AP1G2 ATXN7 CASP3 CCND1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 ITSN2 RAB1A RAB33B RAB4A RAB5A RABGEF1 RGS17 TRIM26 TSC2 UBC YWHAG
Entrez ID		5868	9135
HPRD ID		01542	04684
Ensembl ID		ENSG00000144566	ENSG00000029725
Uniprot IDs		B4DJA5 P20339	F5H355 Q15276
PDB IDs		1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH	1P4U 1TU3 1X79
Enriched GO Terms of Interacting Partners?		Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Protein Transport Protein Localization Establishment Of Protein Localization Establishment Of Localization In Cell Intracellular Transport Transport Cellular Localization Endocytosis Intracellular Protein Transport Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Endosomal Transport Regulation Of Signaling Regulation Of Signal Transduction Membrane Organization Cellular Protein Localization Protein Geranylgeranylation Regulation Of Vesicle-mediated Transport Regulation Of Metabolic Process Vesicle Fusion Membrane Fusion Positive Regulation Of Exocytosis Protein Prenylation Regulation Of Exocytosis Organelle Fusion Golgi To Lysosome Transport Vesicle Organization Intracellular Signal Transduction Ras Protein Signal Transduction Lysosomal Transport Golgi To Vacuole Transport Plasma Membrane To Endosome Transport Cytoplasmic Transport Signaling Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion	Intracellular Protein Transport Intracellular Transport Establishment Of Localization In Cell Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Protein Localization Transport Rab Protein Signal Transduction Regulation Of Vesicle-mediated Transport Membrane Organization Positive Regulation Of Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Intracellular Signal Transduction Endocytosis Regulation Of Endocytosis Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity Signal Transduction Negative Regulation Of Protein Phosphorylation Regulation Of Signaling Regulation Of Cellular Component Organization Small GTPase Mediated Signal Transduction Virion Assembly Positive Regulation Of Hydrolase Activity Apoptotic Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Cytoplasmic Transport Signaling Regulation Of Metabolic Process Positive Regulation Of GTPase Activity Regulation Of Signal Transduction Cellular Response To Stimulus Cell Communication Regulation Of Protein Kinase Activity Negative Regulation Of Signaling Negative Regulation Of Exocytosis Protein Targeting
Tagcloud ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly golgi gtpases liposomes localize master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples gga1 golgi gps localize milieu module must pc1 pc2 polycystic polycystin proper proteolytically reach sense tgn traffic trafficking transmembrane tubular whereby
Tagcloud (Difference) ?		accelerated anchored apposing confer directionality effectors endomembrane endosomal enigmatic exactly gtpases liposomes master membrane organelles rab2a rab7a rabs reconstitution representative reversible strictly strikingly tethering tethers thoroughly	adpkd arl3 autosomal cilia ciliary ciliopathies cleaved couples gga1 gps milieu module must pc1 pc2 polycystic polycystin proper proteolytically reach sense tgn traffic trafficking transmembrane tubular whereby
Tagcloud (Intersection) ?		golgi localize