TCN2

Name	transcobalamin 2
Structure
Novel Interactors	1 novel interactors: PLEKHF2
Interactors	4 interactors: APP CBL PAXIP1 RHOU
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane External Side Of Plasma Membrane Lysosomal Lumen
	Molecular Function	Protein Binding Cobalamin Binding Metal Ion Binding Molecular Carrier Activity Cargo Receptor Ligand Activity
	Biological Process	Monoatomic Ion Transport Cobalt Ion Transport Cobalamin Transport
Pathways	Defective TCN2 causes TCN2 deficiency Defective CD320 causes MMATC Transport of RCbl within the body
GWAS	Blood protein levels ( 30072576 ) Factor VIII levels ( 30586737 ) Gut microbiota relative abundance (Blautia) ( 33208821 ) Moyamoya disease ( 29273593 ) Type 2 diabetes ( 32794382 ) Venous thromboembolism ( 31420334 ) vWF levels ( 30586737 )
Entrez ID	6948
HPRD ID	02037
Ensembl ID	ENSG00000185339
Uniprot IDs	P20062
PDB IDs	2BB5 4ZRP 4ZRQ 5NO0 5NP4 5NRP 5NSA 7QBD 7QBE 7QBF 7QBG
GO Terms Enriched among Interactors ?	Response To Nerve Growth Factor Ephrin Receptor Binding Positive Regulation Of Receptor-mediated Endocytosis Vesicle-mediated Transport Cellular Response To Nerve Growth Factor Stimulus Endocytosis Response To Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Growth Cone Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Ionizing Radiation Chorion Development Membrane Raft Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Early Endosome Membrane Axon Midline Choice Point Recognition Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Rap Protein Signal Transduction Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Ubiquitin-dependent Endocytosis