KIAA1191 and CACNA1A

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		KIAA1191	CACNA1A
Description		KIAA1191	calcium voltage-gated channel subunit alpha1 A
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse
	Molecular Function	Protein Binding Oxidoreductase Activity	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding
	Biological Process		Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta
Pathways			Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs			Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS			Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		9 interacting genes: APP CACNA1A GSK3B NOL12 NOTCH1 POT1 PRNP RHOU SNCA	92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233
Entrez ID		57179	773
HPRD ID		13839	03004
Ensembl ID		ENSG00000122203	ENSG00000141837
Uniprot IDs		A0A087WT18 Q96A73	A0A087WW63 B5TYJ1 O00555 Q9NS89
PDB IDs			3BXK 8X90 8X91 8X93
Enriched GO Terms of Interacting Partners?		Cellular Response To Amyloid-beta Response To Amyloid-beta Cellular Response To Copper Ion Response To Copper Ion Neuron Projection Organization Regulation Of Long-term Synaptic Potentiation Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Apoptotic Process Postsynapse Positive Regulation Of Programmed Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Apoptotic Process Cuprous Ion Binding Positive Regulation Of Establishment Of Protein Localization Regulation Of Calcium-mediated Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Negative Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Copper Ion Homeostasis Regulation Of Cellular Component Organization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Copper Ion Homeostasis Inclusion Body Regulation Of Protein Localization Regulation Of Neurotransmitter Uptake Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Protein Localization Negative Regulation Of Calcium-mediated Signaling Regulation Of Presynapse Organization Negative Regulation Of Wnt Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Molecular Function Activator Activity Cellular Response To Metal Ion Negative Regulation Of Stem Cell Differentiation Regulation Of Establishment Of Protein Localization Amyloid Fibril Formation Regulation Of Neuron Differentiation Microglial Cell Activation Positive Regulation Of Cellular Component Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Exocytosis Regulation Of Calcineurin-mediated Signaling Regulation Of Calcium Ion Transport Import Into Cell	Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome
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