ERF and CSNK1A1

Number of citations of the paper that reports this interaction (PubMedID 12062430)
0

Data Source:
HPRD (in vitro)

		ERF	CSNK1A1
Description		ETS2 repressor factor	casein kinase 1 alpha 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Chromosome, Centromeric Region Kinetochore Nucleus Chromosome Cytoplasm Centrosome Spindle Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Cytoskeleton Cilium Membrane Nuclear Speck Beta-catenin Destruction Complex Ciliary Basal Body Cell Projection Keratin Filament
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation	Autophagosome Assembly Protein Phosphorylation Golgi Organization Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Wnt Signaling Pathway Viral Protein Processing Regulation Of Wnt Signaling Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Cellular Response To Nutrient Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Rho Protein Signal Transduction TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Intermediate Filament Cytoskeleton Organization Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Oncogene Induced Senescence Oncogene Induced Senescence	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Activation of SMO Activation of SMO Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Maturation of nucleoprotein
Drugs			Fostamatinib
Diseases
GWAS		Meat-related diet ( 32066663) Monocyte count ( 27863252)	Carotid intima media thickness x smoking interaction ( 32117412) Chronic obstructive pulmonary disease ( 30804561) Esophageal cancer ( 21642993)
Interacting Genes		10 interacting genes: CSNK1A1 EPHB2 HMGB1 MAPK1 MCRS1 MEOX2 RHOU SPOP TLE5 XPO1	51 interacting genes: ACTB ADAP1 AP3B1 AP3B2 APC ATM AXIN1 BID CDC25A CEBPA CHRM3 CRBN CREM CTNNB1 CUL4B EIF2B5 ERF FADD GLI3 GNB2 HMGB1 HMGB2 HNRNPC HSPA4 KPNA2 KPNB1 LGALS3 MDM4 NFATC3 NLRP3 OCLN PDE4D PHLPP1 PPP1CC PPP1R14A PPP2R5A PSEN2 PTEN RCC1 SLC18A2 SNCA SQSTM1 SYT9 TGFBR1 TIAM1 TNFRSF1B TP53 USP15 UVRAG YWHAQ YWHAZ
Entrez ID		2077	1452
HPRD ID		09942	02739
Ensembl ID		ENSG00000105722	ENSG00000113712
Uniprot IDs		P50548	B4DER9 P48729 Q6PJ06
PDB IDs		7JSA 7JSL	5FQD 6GZD 7WTT 8G66
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anoikis Regulation Of Signal Transduction Response To Peptide Regulation Of Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Response To Cytokine Negative Regulation Of Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nuclear Speck Protein Modification Process Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Cellular Component Organization Phosphorylation Chromosome, Centromeric Region Regulation Of Cellular Component Organization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Phosphorylation Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase Activity Positive Regulation Of Autophagy Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Negative Regulation Of Protein-containing Complex Assembly Kinetochore Regulation Of Wound Healing Regulation Of Cellular Localization Vesicle-mediated Intercellular Transport Optic Nerve Morphogenesis Regulation Of Cell Migration Positive Regulation Of Lymphocyte Proliferation Regulation Of Locomotion Roof Of Mouth Development Hindbrain Tangential Cell Migration Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Production Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Cell Migration Postsynaptic Membrane Assembly Positive Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission Positive Regulation Of Mononuclear Cell Proliferation	Protein-containing Complex Signal Transduction Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Immune System Process Regulation Of Cell Development Ubiquitin Protein Ligase Binding Protein Domain Specific Binding Regulation Of Cell Activation Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Development Cytosol Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Cellular Component Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Differentiation Regulation Of RNA Metabolic Process Regulation Of T Cell Activation Regulation Of Metabolic Process Regulation Of Stem Cell Proliferation T Cell Differentiation In Thymus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Differentiation Regulation Of Lymphocyte Activation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Cell Population Proliferation Lung Development Regulation Of Cellular Component Organization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Cytoplasm Regulation Of Organelle Organization Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Apoptotic Process
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