ABCD1 and ABCD2

Number of citations of the paper that reports this interaction (PMID 10551832)
20

Data Source:
HPRD (two hybrid, in vivo)

		ABCD1	ABCD2
Gene Name		ATP-binding cassette, sub-family D (ALD), member 1	ATP-binding cassette, sub-family D (ALD), member 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Cytosol Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Peroxisome Peroxisomal Membrane Cytosol Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transporter Activity Peroxisomal Fatty-acyl-CoA Transporter Activity Protein Binding ATP Binding ATPase Activity Enzyme Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Identical Protein Binding Protein Homodimerization Activity	Protein Binding ATP Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Protein Homodimerization Activity
	Biological Process	Fatty Acid Beta-oxidation Peroxisome Organization Peroxisomal Long-chain Fatty Acid Import Peroxisomal Membrane Transport Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Catabolic Process Linoleic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Transmembrane Transport	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Very Long-chain Fatty Acid Catabolic Process Transmembrane Transport
Pathways		alpha-linolenic acid (ALA) metabolism ABC-family proteins mediated transport Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism Beta-oxidation of very long chain fatty acids ABCA transporters in lipid homeostasis Peroxisomal lipid metabolism	ABC-family proteins mediated transport ABCA transporters in lipid homeostasis
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ABCD2 ABCD3 PEX19 RPSA SLC27A2	3 interactors: ABCD1 ABCD3 PEX19
Entrez ID		215	225
HPRD ID		02300	03051
Ensembl ID		ENSG00000101986
Uniprot IDs		P33897	Q9UBJ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Very Long-chain Fatty Acid Catabolic Process Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Cellular Lipid Catabolic Process Lipid Modification Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Peroxisome Organization Monocarboxylic Acid Metabolic Process Catabolic Process Negative Regulation Of Lipid Binding Methyl-branched Fatty Acid Metabolic Process RRNA Export From Nucleus Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Transport Protein Targeting To Membrane Cellular Lipid Metabolic Process Carboxylic Acid Metabolic Process Peroxisome Membrane Biogenesis Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Establishment Of Protein Localization To Membrane RRNA Transport Organic Acid Metabolic Process RRNA 3'-end Processing Fatty Acid Alpha-oxidation Long-chain Fatty Acid Import Lipid Metabolic Process Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Peroxisomal Membrane Transport Establishment Of Protein Localization To Organelle Ribosomal Small Subunit Assembly Positive Regulation Of Fatty Acid Beta-oxidation Protein Localization To Membrane Oxidation-reduction Process Peroxisome Fission Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Protein Targeting Maturation Of 5.8S RRNA Transmembrane Transport Positive Regulation Of Fatty Acid Oxidation Regulation Of Fatty Acid Beta-oxidation Protein Localization To Organelle Bile Acid Biosynthetic Process Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Protein Targeting To Peroxisome	Peroxisome Organization Very Long-chain Fatty Acid Catabolic Process Peroxisomal Membrane Transport Very Long-chain Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Cellular Lipid Catabolic Process Negative Regulation Of Lipid Binding Peroxisomal Long-chain Fatty Acid Import Lipid Modification Carboxylic Acid Catabolic Process Lipid Catabolic Process Transmembrane Transport Peroxisome Membrane Biogenesis Fatty Acid Metabolic Process Chaperone-mediated Protein Transport Protein Import Into Peroxisome Membrane Long-chain Fatty Acid Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Peroxisome Fission Monocarboxylic Acid Metabolic Process Organelle Organization Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Membrane Biogenesis Cellular Lipid Metabolic Process Long-chain Fatty Acid Transport Carboxylic Acid Metabolic Process Intracellular Protein Transmembrane Transport Organic Acid Metabolic Process Protein Transmembrane Transport Fatty Acid Transport Chaperone-mediated Protein Folding Lipid Metabolic Process Transport Protein Stabilization Oxidation-reduction Process Intracellular Transport Negative Regulation Of Binding Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Catabolic Process Monocarboxylic Acid Transport Regulation Of Protein Stability Protein Import Establishment Of Localization In Cell
Tagcloud ?		abcd4 belonging cassette cho eukaryotes fungi gfp h0 homologs hydropathy hydrophobic lacking localization lost mammals metazoan motif nh2 organelle peroxisomes plot possesses possessing segment subcellular subfamily terminal	abcd1 accessibility acne adrenoleukodystrophy ald allogeneic allowing cald cis compensate curative demyelination devastating eighteen fivefold fourfold halt hsct hypothesize immediately manifest metabolically monocytes nevertheless peroxisomal retinoids thp urgently virtually
Tagcloud (Difference) ?		abcd4 belonging cassette cho eukaryotes fungi gfp h0 homologs hydropathy hydrophobic lacking localization lost mammals metazoan motif nh2 organelle peroxisomes plot possesses possessing segment subcellular subfamily terminal	accessibility acne adrenoleukodystrophy ald allogeneic allowing cald cis compensate curative demyelination devastating eighteen fivefold fourfold halt hsct hypothesize immediately manifest metabolically monocytes nevertheless peroxisomal retinoids thp urgently virtually
Tagcloud (Intersection) ?		abcd1