ABCD1 and ABCD2

Number of citations of the paper that reports this interaction (PubMedID 10551832)
0

Data Source:
HPRD (in vivo, two hybrid)

		ABCD1	ABCD2
Description		ATP binding cassette subfamily D member 1	ATP binding cassette subfamily D member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Mitochondrial Membrane Perinuclear Region Of Cytoplasm	Peroxisome Peroxisomal Membrane Cytosol Membrane
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Organophosphate Ester Transmembrane Transporter Activity ABC-type Fatty-acyl-CoA Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity Enzyme Binding ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Amide Transmembrane Transporter Activity ADP Binding Fatty Acyl-CoA Hydrolase Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity Sulfur Compound Transmembrane Transporter Activity	Nucleotide Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding ATP Binding Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Hydrolase Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity Amide Transmembrane Transporter Activity Protein Heterodimerization Activity Fatty Acyl-CoA Hydrolase Activity ABC-type Transporter Activity Sulfur Compound Transmembrane Transporter Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Regulation Of Oxidative Phosphorylation Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Peroxisome Organization Organophosphate Ester Transport Long-chain Fatty Acid Import Into Peroxisome Fatty-acyl-CoA Transport Peroxisomal Membrane Transport Nucleobase-containing Compound Transport Regulation Of Fatty Acid Metabolic Process Fatty Acid Elongation Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Long-chain Fatty Acid Catabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Amide Transport Myelin Maintenance Linoleic Acid Metabolic Process Regulation Of Mitochondrial Depolarization Transmembrane Transport Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cellular Response To Oxidative Stress Fatty Acid Derivative Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process	Very Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Peroxisome Organization Response To Bacterium Organophosphate Ester Transport Long-chain Fatty Acid Import Into Peroxisome Nucleobase-containing Compound Transport Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Fatty Acid Beta-oxidation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Catabolic Process Amide Transport Myelin Maintenance Linoleic Acid Metabolic Process Transmembrane Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Fatty Acid Derivative Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Neuron Projection Maintenance Positive Regulation Of Unsaturated Fatty Acid Biosynthetic Process
Pathways		ABC transporters in lipid homeostasis Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Defective ABCD1 causes ALD Class I peroxisomal membrane protein import	ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import
Drugs
Diseases		Adrenoleukodystrophy (ALD), including: Schilder-Addison Complex; Childhood cerebral adrenoleukodystrophy (CCER); adrenomyeloneuropathy (AMN)
GWAS		Glycated hemoglobin levels ( 34059833)
Interacting Genes		5 interacting genes: ABCD2 ABCD3 PEX19 RPSA SLC27A2	3 interacting genes: ABCD1 ABCD3 PEX19
Entrez ID		215	225
HPRD ID		02300	03051
Ensembl ID		ENSG00000101986	ENSG00000173208
Uniprot IDs		P33897	Q9UBJ2
PDB IDs		7RR9 7RRA 7SHM 7SHN 7VR1 7VWC 7VX8 7VZB 7X07 7X0T 7X0Z 7X1W 7XEC 7YRQ
Enriched GO Terms of Interacting Partners?		Very Long-chain Fatty Acid Catabolic Process Peroxisomal Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Peroxisomal Membrane Transport Peroxisome Peroxisome Organization Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Long-chain Fatty Acid Import Into Peroxisome Methyl-branched Fatty Acid Metabolic Process Fatty Acid Oxidation Fatty Acid Catabolic Process Lipid Oxidation Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Transport Fatty Acyl-CoA Hydrolase Activity Lipid Modification Bile Acid Biosynthetic Process Carboxylic Acid Catabolic Process ATPase-coupled Transmembrane Transporter Activity Bile Acid Metabolic Process Intracellular Lipid Transport Carboxylic Acid Transport Organic Acid Transport Carboxylic Acid Biosynthetic Process Lipid Catabolic Process ABC-type Transporter Activity Fatty Acid Metabolic Process Lipid Transport Fatty Acid Derivative Biosynthetic Process Organic Anion Transport Intracellular Transport Fatty Acid Derivative Metabolic Process Small Molecule Biosynthetic Process Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Monocarboxylic Acid Metabolic Process Lipid Biosynthetic Process Fatty Acid Biosynthetic Process Organophosphate Ester Transmembrane Transporter Activity Nucleobase-containing Compound Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Peroxisome Membrane Targeting Sequence Binding Phytanic Acid Metabolic Process Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Cholate-CoA Ligase Activity Organic Acid Transmembrane Transport	Peroxisomal Membrane Transport Peroxisome Organization Peroxisomal Membrane Long-chain Fatty Acid Import Into Peroxisome Peroxisome Very Long-chain Fatty Acid Catabolic Process Fatty Acyl-CoA Hydrolase Activity Long-chain Fatty Acid Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Very Long-chain Fatty Acid Metabolic Process Intracellular Lipid Transport ABC-type Transporter Activity Long-chain Fatty Acid Transport Fatty Acid Beta-oxidation Fatty Acid Oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Very Long-chain Fatty-acyl-CoA Catabolic Process Monocarboxylic Acid Transport Organic Acid Transmembrane Transport ABC-type Fatty-acyl-CoA Transporter Activity Carboxylic Acid Transmembrane Transport Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Lipid Modification Very Long-chain Fatty-acyl-CoA Metabolic Process Organophosphate Ester Transmembrane Transporter Activity Very Long-chain Fatty Acyl-CoA Hydrolase Activity Nucleobase-containing Compound Transmembrane Transporter Activity Intracellular Transport Peroxisome Membrane Targeting Sequence Binding Phytanic Acid Metabolic Process Sulfur Compound Transmembrane Transporter Activity Fatty-acyl-CoA Transport Amide Transmembrane Transporter Activity Carboxylic Acid Catabolic Process Peroxisome Membrane Biogenesis Cellular Localization Carboxylic Acid Transport Organic Acid Transport Carboxylic Acid Biosynthetic Process Lipid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Establishment Of Localization In Cell Fatty-acyl-CoA Catabolic Process Fatty Acid Metabolic Process Lipid Transport
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