Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
BARD1 and H2AFX
Number of citations of the paper that reports this interaction (PMID
12485996
)
52
Data Source:
BioGRID
(pull down)
BARD1
H2AFX
Gene Name
BRCA1 associated RING domain 1
H2A histone family, member X
Image
Gene Ontology Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
BRCA1-BARD1 Complex
Intracellular Membrane-bounded Organelle
BRCA1-A Complex
Chromosome, Telomeric Region
Nucleosome
Nuclear Chromatin
Condensed Nuclear Chromosome
Male Germ Cell Nucleus
XY Body
Nucleus
Nucleoplasm
Replication Fork
Site Of Double-strand Break
Extracellular Vesicular Exosome
Molecular Function
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
DNA Binding
Damaged DNA Binding
Protein Binding
Enzyme Binding
Histone Binding
Protein Heterodimerization Activity
Biological Process
Tissue Homeostasis
DNA Repair
Cellular Response To DNA Damage Stimulus
Cell Cycle Arrest
Protein Ubiquitination
Negative Regulation Of MRNA 3'-end Processing
Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Protein Export From Nucleus
Protein K6-linked Ubiquitination
DNA Damage Checkpoint
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Double-strand Break Repair
Nucleosome Assembly
Cellular Response To DNA Damage Stimulus
Spermatogenesis
Response To Ionizing Radiation
Positive Regulation Of DNA Repair
Meiotic Cell Cycle
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
Regulatory RNA pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Cellular Senescence
Signaling by Wnt
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
RNF mutants show enhanced WNT signaling and proliferation
Homologous recombination repair of replication-independent double-strand breaks
ATM mediated phosphorylation of repair proteins
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
ATM mediated response to DNA double-strand break
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Chromatin organization
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Senescence-Associated Secretory Phenotype (SASP)
Chromatin modifying enzymes
Recruitment of repair and signaling proteins to double-strand breaks
SIRT1 negatively regulates rRNA Expression
Condensation of Prophase Chromosomes
MRN complex relocalizes to nuclear foci
RNA Polymerase I Promoter Clearance
Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
M Phase
Telomere Maintenance
Nucleosome assembly
XAV939 inhibits tankyrase, stabilizing AXIN
Double-Strand Break Repair
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
RNA Polymerase I Transcription
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Cell Cycle, Mitotic
PRC2 methylates histones and DNA
RMTs methylate histone arginines
TCF dependent signaling in response to WNT
Oxidative Stress Induced Senescence
Homologous Recombination Repair
RNA Polymerase I Promoter Opening
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Neuroblastoma (
22941191
21124317
)
Neuroblastoma (high-risk) (
19412175
)
Protein-Protein Interactions
107 interactors:
ACP1
AKIP1
AP1B1
ASH2L
ATP1B1
ATP1B3
BCCIP
BCL3
BRCA1
BRD7
BRIP1
CAP1
CASC1
CCDC136
CEP70
CHD3
CNTN4
COL1A1
COMMD1
CRIPAK
CSTF1
DCC
DDX39B
EWSR1
EXOC5
FAM9B
FEZ1
FKBP1A
FKBP2
FKBP3
FUCA1
GIT1
GOLGA2
GPRASP2
H2AFX
HAP1
HIST2H2AC
HNRNPC
HNRNPLL
HSPA14
IDI1
IKBKAP
ING5
KAT5
KAT7
KBTBD7
KRT40
LDOC1
LGALS3
LGALS8
LRIF1
MDC1
MRPS22
MSH2
MSH3
MSH6
MT2A
ND1
NFKBIA
NPC2
OLA1
PCBP2
PDXK
PDZD8
PIAS1
PIAS4
POLR2A
POLR2H
POMZP3
POU2F1
PSMA7
PTN
RBBP8
RBMY2BP
RPS20
SELENBP1
SETDB1
SMCHD1
SNRNP200
SNX3
SPAG5
SRSF2
TCERG1
TMEM248
TOP1
TP53
TRAF1
TRAPPC11
TRAPPC8
TULP2
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2N
UBE2U
UBE2W
UBE3A
UBR5
UBXN1
WDR61
XRCC6
ZFP64
ZHX1
ZNF121
45 interactors:
A2M
ACTB
ALG9
ATM
ATR
BARD1
BMI1
BRCA1
BRCA2
BRD1
CALM1
COPG1
DDX21
DHX9
KAT5
MASP1
MCPH1
MDC1
MRE11A
NBN
NCL
NGFR
OTUB1
PAXIP1
PBK
PPP1CA
PPP2R4
PRKDC
QARS
RNF168
RNF8
RPS6KA3
SMARCA4
SSRP1
SUPT16H
SUPT5H
TAF1C
TAF5L
TERF2
TIAM2
TOPORS
TP53BP1
TSSK6
WRN
XRCC6
Entrez ID
580
3014
HPRD ID
03354
03465
Ensembl ID
ENSG00000138376
ENSG00000188486
Uniprot IDs
Q99728
P16104
PDB IDs
1JM7
2NTE
2R1Z
3C5R
3FA2
2D31
2DYP
3SHV
3SQD
3SZM
3U3Z
Enriched GO Terms of Interacting Partners
?
Cellular Response To DNA Damage Stimulus
DNA Repair
Protein Polyubiquitination
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Response To Stress
Nitrogen Compound Metabolic Process
Double-strand Break Repair
DNA Metabolic Process
Gene Expression
Chromosome Organization
Regulation Of Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of Nitrogen Compound Metabolic Process
RNA Metabolic Process
Protein Modification By Small Protein Conjugation
RNA Biosynthetic Process
Transcription, DNA-templated
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Response To Stress
Cell Cycle Checkpoint
DNA Recombination
Negative Regulation Of Cellular Metabolic Process
Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Cellular Metabolic Process
Meiotic Mismatch Repair
Cellular Macromolecule Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Nucleic Acid-templated Transcription
Modification-dependent Protein Catabolic Process
Chromatin Organization
DNA Damage Checkpoint
Cellular Macromolecule Catabolic Process
Immune System Process
Viral Process
Cell Cycle
Proteolysis Involved In Cellular Protein Catabolic Process
Organelle Organization
Cellular Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Transcription, DNA-templated
DNA Metabolic Process
Double-strand Break Repair
DNA Repair
Cellular Response To DNA Damage Stimulus
Chromosome Organization
DNA Recombination
Organelle Organization
Cellular Response To Stress
Response To Ionizing Radiation
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Response To Radiation
Chromatin Organization
Response To Stress
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Chromatin Modification
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Abiotic Stimulus
Telomere Maintenance
Nitrogen Compound Metabolic Process
Positive Regulation Of Metabolic Process
Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Signal Transduction In Response To DNA Damage
Regulation Of Protein Metabolic Process
Cellular Metabolic Process
Histone Modification
Signal Transduction By P53 Class Mediator
Response To Stimulus
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle
Cellular Response To Stimulus
Cellular Protein Modification Process
DNA Damage Response, Signal Transduction By P53 Class Mediator
Regulation Of Nitrogen Compound Metabolic Process
Peptidyl-amino Acid Modification
DNA Damage Checkpoint
Peptidyl-lysine Modification
Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
DNA Replication
Regulation Of Gene Expression
Response To Gamma Radiation
Negative Regulation Of Protein Metabolic Process
Histone Acetylation
Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Difference)
?
10ng
agreed
atr
belonged
biosynthetic
biphenyls
brca2
dioxin
fancd2
figf
hands
immunoblots
impulses
kcnma1
lactational
mycn
ndl
neurobiological
npy4r
ontology
operator6
pcbs
performances
projection
rad51
scn1a
summation
transcriptomic
validating
Tagcloud (Intersection)
?