PTPRM and PTPRS

Number of citations of the paper that reports this interaction (PMID 12376545)
13

Data Source:
HPRD (in vivo)

		PTPRM	PTPRS
Gene Name		protein tyrosine phosphatase, receptor type, M	protein tyrosine phosphatase, receptor type, S
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm	Integral Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug Positive Regulation Of Vasodilation	Cell Adhesion Spinal Cord Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Corpus Callosum Development Extracellular Matrix Organization Peptidyl-tyrosine Dephosphorylation
Pathways			ECM proteoglycans
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		9 interactors: CDH1 CTNNB1 CTNND1 GNB2L1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS	23 interactors: CHD3 EEF1G EGFR FEZ1 KAT5 KIAA1377 MOB4 PFN2 PPFIA1 PPFIA2 PPFIA3 PTN PTPRA PTPRD PTPRE PTPRM PTPRN RAB35 SETDB1 TUBB2A UBR1 UNC119 UTP14A
Entrez ID		5797	5802
HPRD ID		01479	03344
Ensembl ID		ENSG00000173482	ENSG00000105426
Uniprot IDs		E7EVX9 P28827	Q13332 Q59FX6 Q8NHS7
PDB IDs		1RPM 2C9A 2V5Y	2FH7 2YD2 2YD3 2YD9 4BPC
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cell Adhesion Regulation Of Wnt Signaling Pathway Digestive Tract Development Digestive System Development Protein Localization To Cell Surface Regulation Of Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Embryonic Development Regulation Of Canonical Wnt Signaling Pathway Protein Dephosphorylation Brain Development Adherens Junction Assembly Regulation Of Epithelial Cell Proliferation Head Development Epithelial Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cell Cycle Regulation Of Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Central Nervous System Development Multicellular Organismal Development Execution Phase Of Apoptosis Anatomical Structure Development Renin Secretion Into Blood Stream Negative Regulation Of Signal Transduction Forebrain Development Embryo Development Dephosphorylation Lens Development In Camera-type Eye Cellular Response To Organonitrogen Compound Negative Regulation Of Signaling Nervous System Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of CAMP Catabolic Process Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Single Organismal Cell-cell Adhesion Regulation Of Embryonic Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epithelial Cell Proliferation	Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Peptidyl-tyrosine Dephosphorylation Glutamate Secretion Protein Dephosphorylation Acid Secretion Dephosphorylation Dicarboxylic Acid Transport Neurotransmitter Secretion Cellular Response To Estradiol Stimulus Regulation Of Neurotransmitter Levels Cellular Response To Estrogen Stimulus Positive Regulation Of Vasodilation Axon Guidance Amino Acid Transport Neuron Differentiation Neurotransmitter Transport Cell Projection Organization Signaling Cell Adhesion Cell Communication Regulation Of Vasodilation Neuron Projection Development Negative Regulation Of Epithelial Cell Migration Response To Estrogen Cell Projection Morphogenesis Cellular Protein Metabolic Process Alkanesulfonate Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Cell Part Morphogenesis Secretion By Cell Enzyme Linked Receptor Protein Signaling Pathway Cell Cycle Cellular Response To Organic Substance Cell-cell Signaling Axonogenesis Cellular Response To Amino Acid Stimulus Regulation Of Stress Fiber Assembly Neuron Development Cellular Protein Modification Process Axon Development Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Cellular Response To Leucine Negative Regulation Of Caveolin-mediated Endocytosis Astrocyte Activation Dense Core Granule Maturation Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Regulation Of Dendrite Morphogenesis Chemotaxis Cell Cycle Process
Tagcloud ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	cd24 cgrp chordoid codelink crb3 ependymal ependymomas hiomt hoxd13 krt18 opn4 phototransduction pineal pineoblastoma pineocytomas pou4f2 ppt ppts rarity rfx3 rgs16 sox4 spedf subcommissural tep1 tph ubec2 zfh4
Tagcloud (Difference) ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	cd24 cgrp chordoid codelink crb3 ependymal ependymomas hiomt hoxd13 krt18 opn4 phototransduction pineal pineoblastoma pineocytomas pou4f2 ppt ppts rarity rfx3 rgs16 sox4 spedf subcommissural tep1 tph ubec2 zfh4
Tagcloud (Intersection) ?