PTPRM and IQGAP1

Number of citations of the paper that reports this interaction (PubMedID 16380380)
0

Data Source:
BioGRID (pull down)

		PTPRM	IQGAP1
Description		protein tyrosine phosphatase receptor type M	IQ motif containing GTPase activating protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Lamellipodium Perinuclear Region Of Cytoplasm	Ruffle Nucleus Cytoplasm Cytosol Microtubule Actin Filament Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Axon Growth Cone Midbody Secretory Granule Membrane Cortical Actin Cytoskeleton Cell Leading Edge Slit Diaphragm Cytoplasmic Ribonucleoprotein Granule Neuron Projection Extracellular Exosome Plasma Membrane Bounded Cell Projection Ribonucleoprotein Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Identical Protein Binding Cadherin Binding	MAP-kinase Scaffold Activity GTPase Inhibitor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Small GTPase Binding Protein Serine/threonine Kinase Activator Activity S100 Protein Binding Cadherin Binding Actin Filament Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Response To Xenobiotic Stimulus Negative Regulation Of Endothelial Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Retina Layer Formation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Neuron Projection Development Retinal Ganglion Cell Axon Guidance D-glucose Transmembrane Transport	MAPK Cascade Regulation Of Cytokine Production Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Fibroblast Growth Factor Receptor Signaling Pathway Fibroblast Migration Cell Migration Negative Regulation Of Dephosphorylation Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Platelet-derived Growth Factor Receptor Signaling Pathway Caveola Assembly Cellular Response To Calcium Ion Cellular Response To Epidermal Growth Factor Stimulus Podocyte Development Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Neuron Projection Extension
Pathways			Nephrin family interactions Glucagon-like Peptide-1 (GLP1) regulates insulin secretion RHO GTPases activate IQGAPs MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RHOV GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Artenimol
Diseases
GWAS		Adult body size ( 32376654) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Chronic postoperative pain ( 31903573) Glaucoma (primary open-angle) ( 33627673) Heel bone mineral density ( 30598549) Heel bone mineral density x serum urate levels interaction ( 34046847) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Male-pattern baldness ( 28196072) Multiple sclerosis ( 24076602) Neutrophil percentage of white cells ( 32888494) Red cell distribution width ( 32888494) Rheumatoid arthritis ( 32868391) White blood cell count (basophil) ( 27863252)
Interacting Genes		12 interacting genes: BCCIP CDH1 CNKSR1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1	45 interacting genes: ACTA1 AIMP1 AKAP5 APC CALM1 CDC42 CDH1 CDK1 CDK2 CEBPA CLIC5 CLIP1 CREBBP CTNNB1 CYBB DSCAM DUX4 EGFR EZR GRIA4 ILF2 KDR LBX1 LCOR MAPK1 MEI4 MEN1 MEOX2 MYL1 NPHS1 NRIP1 NUMB OTX2 PDLIM7 PKNOX2 PRKACA PTPRM RAC1 S100B STAU1 SUMO2 TEPSIN TSG101 UBE2I VASP
Entrez ID		5797	8826
HPRD ID		01479	04541
Ensembl ID		ENSG00000173482	ENSG00000140575
Uniprot IDs		P28827	A0A0J9YXZ5 P46940
PDB IDs		1RPM 2C9A 2V5Y 8A16 8A17	1X0H 2RR8 3FAY 3I6X 5L0O
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell-cell Junction Catenin Complex Cell-cell Adhesion Mediated By Cadherin Cellular Response To Indole-3-methanol Anchoring Junction Response To Indole-3-methanol Cell Cortex Adherens Junction Cell Junction Organization Regulation Of Blood Vessel Branching Lateral Plasma Membrane Cell Adhesion Flotillin Complex Synapse Organization Gamma-catenin Binding Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of Neurogenesis Phosphoprotein Phosphatase Activity Negative Regulation Of Nervous System Development Regulation Of Cell Growth Plasma Membrane Negative Regulation Of Cell Growth Apical Junction Complex Negative Regulation Of Axon Extension Focal Adhesion Protein Localization To Cell Surface Regulation Of Anatomical Structure Morphogenesis Cell-cell Adhesion Mediator Activity Regulation Of Multicellular Organismal Development Extracellular Exosome Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Midbody Molecular Adaptor Activity Cell Migration Cell-cell Adhesion Cell Junction Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Intercalated Disc Negative Regulation Of Growth Gastrulation Negative Regulation Of Axonogenesis Adherens Junction Organization Cell Motility Regulation Of Morphogenesis Of A Branching Structure Glial Cell Fate Determination Phosphatase Binding	Intracellular Signaling Cassette Cadherin Binding Focal Adhesion Positive Regulation Of Protein Localization Developmental Process Lamellipodium Cell-cell Junction Organization Positive Regulation Of Cellular Component Organization Modulation Of Chemical Synaptic Transmission Positive Regulation Of Organelle Organization Cellular Developmental Process Centrosome Intracellular Signal Transduction Glutamatergic Synapse Cell Development Neuron Fate Determination Cell Projection Cytoskeleton Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Regulation Of Protein Localization Cell Junction Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Macromolecule Biosynthetic Process Regulation Of Organelle Organization Regulation Of Cellular Localization Actin Cytoskeleton Adherens Junction Cytoplasm Adherens Junction Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Phosphorylation Regulation Of Cell Cycle Regulation Of RNA Biosynthetic Process Regulation Of Locomotion Regulation Of Synaptic Plasticity Regulation Of Phosphorus Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Cytosol Cyclin-dependent Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Locomotion
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