PTPRM and PTPRA

Number of citations of the paper that reports this interaction (PubMedID 10777529)
0

Data Source:
HPRD (two hybrid, in vivo)

		PTPRM	PTPRA
Description		protein tyrosine phosphatase receptor type M	protein tyrosine phosphatase receptor type A
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Lamellipodium Perinuclear Region Of Cytoplasm	Plasma Membrane Focal Adhesion Membrane Receptor Complex Extracellular Exosome Anchoring Junction
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Identical Protein Binding Cadherin Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Response To Xenobiotic Stimulus Negative Regulation Of Endothelial Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Retina Layer Formation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Neuron Projection Development Retinal Ganglion Cell Axon Guidance D-glucose Transmembrane Transport	Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Focal Adhesion Assembly
Pathways			NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Adult body size ( 32376654) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: BCCIP CDH1 CNKSR1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1	20 interacting genes: BCAR1 CALM1 FYN GABARAPL2 GAS1 GRB2 HSPB1 HUNK KCNA2 LCOR LINC00839 MBP PRKCD PTGER4 PTPRD PTPRF PTPRM PTPRS RET SRC
Entrez ID		5797	5786
HPRD ID		01479	01476
Ensembl ID		ENSG00000173482	ENSG00000132670
Uniprot IDs		P28827	A0A1S5UZ22 B7Z2A4 P18433
PDB IDs		1RPM 2C9A 2V5Y 8A16 8A17	6UZT
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell-cell Junction Catenin Complex Cell-cell Adhesion Mediated By Cadherin Cellular Response To Indole-3-methanol Anchoring Junction Response To Indole-3-methanol Cell Cortex Adherens Junction Cell Junction Organization Regulation Of Blood Vessel Branching Lateral Plasma Membrane Cell Adhesion Flotillin Complex Synapse Organization Gamma-catenin Binding Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of Neurogenesis Phosphoprotein Phosphatase Activity Negative Regulation Of Nervous System Development Regulation Of Cell Growth Plasma Membrane Negative Regulation Of Cell Growth Apical Junction Complex Negative Regulation Of Axon Extension Focal Adhesion Protein Localization To Cell Surface Regulation Of Anatomical Structure Morphogenesis Cell-cell Adhesion Mediator Activity Regulation Of Multicellular Organismal Development Extracellular Exosome Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Midbody Molecular Adaptor Activity Cell Migration Cell-cell Adhesion Cell Junction Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Intercalated Disc Negative Regulation Of Growth Gastrulation Negative Regulation Of Axonogenesis Adherens Junction Organization Cell Motility Regulation Of Morphogenesis Of A Branching Structure Glial Cell Fate Determination Phosphatase Binding	Vascular Endothelial Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Phosphatase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Synaptic Membrane Adhesion Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Protein Tyrosine Phosphatase Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Defense Response Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity T Cell Costimulation Cell-cell Adhesion Phosphoprotein Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Response To Growth Factor Fc Receptor Signaling Pathway Regulation Of Anatomical Structure Morphogenesis Immune Response-activating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Phospholipase Activator Activity Regulation Of Apoptotic Signaling Pathway Immune Effector Process Regulation Of Immune Response Cell-cell Junction Regulation Of Cell Migration ERBB Signaling Pathway Insulin Receptor Substrate Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Membrane Regulation Of Cell Motility Regulation Of Neuron Projection Development Protein Tyrosine Kinase Activator Activity
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