PTPRM and CTNND1

Number of citations of the paper that reports this interaction (PMID 15588985)
37

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro, in vivo)

		PTPRM	CTNND1
Gene Name		protein tyrosine phosphatase, receptor type, M	catenin (cadherin-associated protein), delta 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Lamellipodium Growth Cone Midbody Dendritic Spine Synapse Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding	Receptor Binding Protein Binding Protein Kinase Binding Cadherin Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug Positive Regulation Of Vasodilation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Adhesion Brain Development Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		9 interactors: CDH1 CTNNB1 CTNND1 GNB2L1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS	26 interactors: ACTA1 APP CDH1 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR ERBB2IP FER GRIK2 GSK3B JUP KCTD6 LCK MTNR1B MUC1 PSEN1 PTPN6 PTPRJ PTPRM SNCA SRC YWHAG ZBTB33
Entrez ID		5797	1500
HPRD ID		01479	03026
Ensembl ID		ENSG00000173482	ENSG00000198561
Uniprot IDs		E7EVX9 P28827	C9JZR2 O60716
PDB IDs		1RPM 2C9A 2V5Y	3L6X 3L6Y
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cell Adhesion Regulation Of Wnt Signaling Pathway Digestive Tract Development Digestive System Development Protein Localization To Cell Surface Regulation Of Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Embryonic Development Regulation Of Canonical Wnt Signaling Pathway Protein Dephosphorylation Brain Development Adherens Junction Assembly Regulation Of Epithelial Cell Proliferation Head Development Epithelial Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cell Cycle Regulation Of Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Central Nervous System Development Multicellular Organismal Development Execution Phase Of Apoptosis Anatomical Structure Development Renin Secretion Into Blood Stream Negative Regulation Of Signal Transduction Forebrain Development Embryo Development Dephosphorylation Lens Development In Camera-type Eye Cellular Response To Organonitrogen Compound Negative Regulation Of Signaling Nervous System Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of CAMP Catabolic Process Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Single Organismal Cell-cell Adhesion Regulation Of Embryonic Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epithelial Cell Proliferation	Cell Adhesion Adherens Junction Organization Regulation Of Signaling Single Organismal Cell-cell Adhesion Regulation Of Signal Transduction Regulation Of Cellular Localization Regulation Of Intracellular Transport Cellular Response To Organonitrogen Compound Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Junction Assembly Cell-cell Junction Organization Locomotion Cellular Response To Stimulus Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Cellular Amino Acid Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Negative Regulation Of Protein Metabolic Process Signaling Negative Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of ERBB Signaling Pathway Regulation Of Cellular Protein Metabolic Process Apoptotic Process Regulation Of Cellular Ketone Metabolic Process Signal Transduction Regulation Of Protein Kinase Activity Response To Drug Programmed Cell Death Cell Death Death Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Developmental Process Negative Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Mechanical Stimulus Anatomical Structure Development Response To Organonitrogen Compound Response To External Stimulus Regulation Of Apoptotic Process Cell Migration Regulation Of Cell Proliferation Positive Regulation Of Intracellular Transport
Tagcloud ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	abi1 atlas bitbucket ccnd3 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 ralgds regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Intersection) ?