PTPRM and GNB2L1

Number of citations of the paper that reports this interaction (PMID 11278757)
28

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PTPRM	GNB2L1
Gene Name		protein tyrosine phosphatase, receptor type, M	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Integral Component Of Plasma Membrane Cell-cell Junction Cell-cell Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm	Phagocytic Cup Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding	Protein Kinase C Binding Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Receptor Tyrosine Kinase Binding Protein Complex Scaffold SH2 Domain Binding Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug Positive Regulation Of Vasodilation	Osteoblast Differentiation Positive Regulation Of Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of CAMP Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Homooligomerization Regulation Of Protein Localization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767)
Protein-Protein Interactions		9 interactors: CDH1 CTNNB1 CTNND1 GNB2L1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS	86 interactors: ADH1B ADRB2 AGTRAP AR AURKB BCL2L11 CCNA1 CDKN1A CHERP CSF2RB DDX19B DGCR14 DNM1 DYNLL1 EIF6 EPOR FBXW7 FYN GABRB3 GNB1 GOLM1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IFNR IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MKRN2 NFATC1 NR3C1 NSMAF PABPC1 PDE4D PLCG1 PLEC PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TCEB1 TCEB2 TNFRSF1A TP63 TP73 TSC22D4 TUBB TYK2 WDR83
Entrez ID		5797	10399
HPRD ID		01479	01503
Ensembl ID		ENSG00000173482	ENSG00000204628
Uniprot IDs		E7EVX9 P28827	E9KL35 P63244
PDB IDs		1RPM 2C9A 2V5Y	3J3A 4AOW
Enriched GO Terms of Interacting Partners?		Adherens Junction Organization Cell Junction Assembly Cell-cell Junction Organization Cellular Response To Indole-3-methanol Cell Adhesion Regulation Of Wnt Signaling Pathway Digestive Tract Development Digestive System Development Protein Localization To Cell Surface Regulation Of Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Embryonic Development Regulation Of Canonical Wnt Signaling Pathway Protein Dephosphorylation Brain Development Adherens Junction Assembly Regulation Of Epithelial Cell Proliferation Head Development Epithelial Cell Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Cell Cycle Regulation Of Morphogenesis Of A Branching Structure Cellular Response To Organic Substance Central Nervous System Development Multicellular Organismal Development Execution Phase Of Apoptosis Anatomical Structure Development Renin Secretion Into Blood Stream Negative Regulation Of Signal Transduction Forebrain Development Embryo Development Dephosphorylation Lens Development In Camera-type Eye Cellular Response To Organonitrogen Compound Negative Regulation Of Signaling Nervous System Development Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of CAMP Catabolic Process Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Single Organismal Cell-cell Adhesion Regulation Of Embryonic Development Developmental Process Anatomical Structure Morphogenesis Negative Regulation Of Epithelial Cell Proliferation	Signaling Cell Communication Cellular Response To Stimulus Signal Transduction Response To Stimulus Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Response To External Stimulus Defense Response Viral Process Response To Stress Immune System Process Regulation Of Immune Response Regulation Of Body Fluid Levels Regulation Of Cell Proliferation Regulation Of Immune System Process Response To Abiotic Stimulus Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Signal Transduction Regulation Of Cellular Localization Response To Cytokine Regulation Of Cell Death Regulation Of Cellular Process Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Platelet Activation Innate Immune Response Immune Response Regulation Of Phosphorylation Blood Coagulation Regulation Of Apoptotic Process Hemostasis Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of Transport Peptidyl-tyrosine Autophosphorylation Cellular Process Neurotrophin TRK Receptor Signaling Pathway Developmental Process Regulation Of Angiogenesis Positive Regulation Of Cellular Metabolic Process
Tagcloud ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Difference) ?		12q21 18p11 20q12 7q31 aberrations amplified braf chromosomal colorectal connected covering deleted deletions gains glioma hypermethylated losses methylator molecularly oncogenes phosphatases ptprq ptprt ptprz1 ptps sporadic suppressors unbalanced z1	aiming aip alignment boar brms1 chordc1 clues cops6 csde1 csfv ddx5 domestic fever hemorrhagic hspa8 interactive metap2 nav1 ncbi ns5a phf5a polr1c ppp2r3c psmc3 suvec swine tmed10 tmem70 y2h
Tagcloud (Intersection) ?