PTPRM

Description		protein tyrosine phosphatase receptor type M
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Membrane Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Identical Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Endothelial Cell Proliferation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Response To Xenobiotic Stimulus Negative Regulation Of Endothelial Cell Migration Positive Regulation Of D-glucose Transmembrane Transport Negative Regulation Of D-glucose Transmembrane Transport Retina Layer Formation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Migration Neuron Projection Development Retinal Ganglion Cell Axon Guidance D-glucose Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)
Novel Interacting Genes		1 novel interacting genes: AKAP6
Interacting Genes		12 interacting genes: BCCIP CDH1 CNKSR1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1
Entrez ID		5797
HPRD ID		01479
Ensembl ID		ENSG00000173482
Uniprot IDs		P28827
PDB IDs		1RPM 2C9A 2V5Y 8A16 8A17
Enriched GO Terms of Interacting Partners?		Cadherin Binding Cell-cell Junction Catenin Complex Cell-cell Adhesion Mediated By Cadherin Cellular Response To Indole-3-methanol Anchoring Junction Response To Indole-3-methanol Cell Cortex Adherens Junction Cell Junction Organization Regulation Of Blood Vessel Branching Lateral Plasma Membrane Cell Adhesion Flotillin Complex Synapse Organization Gamma-catenin Binding Protein Phosphatase Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of Neurogenesis Phosphoprotein Phosphatase Activity Negative Regulation Of Nervous System Development Regulation Of Cell Growth Plasma Membrane Negative Regulation Of Cell Growth Apical Junction Complex Negative Regulation Of Axon Extension Focal Adhesion Protein Localization To Cell Surface Regulation Of Anatomical Structure Morphogenesis Cell-cell Adhesion Mediator Activity Regulation Of Multicellular Organismal Development Extracellular Exosome Cellular Response To Oxygen-containing Compound Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Midbody Molecular Adaptor Activity Cell Migration Cell-cell Adhesion Cell Junction Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Intercalated Disc Negative Regulation Of Growth Gastrulation Negative Regulation Of Axonogenesis Adherens Junction Organization Cell Motility Regulation Of Morphogenesis Of A Branching Structure Glial Cell Fate Determination Phosphatase Binding
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