TRIB3 and EEF1G

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		TRIB3	EEF1G
Description		tribbles pseudokinase 3	eukaryotic translation elongation factor 1 gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Ligase Activator Activity	Translation Elongation Factor Activity Protein Binding Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Autophagy Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Translation Translational Elongation Response To Virus
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Eukaryotic Translation Elongation Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		100 interacting genes: ACACA AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MDM2 MISP MYC OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PRKAB2 PRMT5 PRR19 PSMA3 RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SAXO4 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587	100 interacting genes: ABCC9 ADAP2 AKT1 ANKRD28 ARF1 ARIH2 C11orf58 C1orf174 CARS1 CBX8 CCDC106 CCT7 CDC42 CDK2AP2 CDK5RAP2 CEBPA CHFR CRELD1 CSTF2 CXCL13 DKC1 DLEU1 DLG4 DRD3 DYSF ECH1 EEF1B2 EEF1D EEF1DP3 EFNA1 EID2B EIF4ENIF1 ENOX1 FAM200C FEN1 FOXG1 GADD45A GADD45G GET4 GSK3B GSTO1 HARS1 HDAC5 HLTF HMOX2 HNRNPH3 ILF2 KARS1 KLHL18 LARS1 LINC01554 LZTS1 MBD1 MCRIP2 MED31 MLH1 MTNR1A MVD NADK NCK2 NDRG1 NUDT21 NUDT3 NUP85 OGFOD2 OGT PDCD5 PHACTR3 PLEKHA4 PLGRKT PSMD11 PTK2 PTPN4 PTPRF PTPRS RBM6 RECQL5 RGL2 RNF26 RPL4P5 RPS28 SAT1 SFRP2 SKIL SLC22A2 SNAPIN SNRPD2 SUMO2 TNNT1 TP53I3 TRIB3 TRIM55 TRIM63 TUBB3 UCHL5 USP7 WDR33 YWHAG ZDHHC17 ZNF24
Entrez ID		57761	1937
HPRD ID		09836	11745
Ensembl ID		ENSG00000101255	ENSG00000254772
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	P26641 Q53YD7
PDB IDs			1PBU 5DQS 5JPO
Enriched GO Terms of Interacting Partners?		Nucleus Protein Binding Negative Regulation Of Gene Expression DNA-binding Transcription Factor Binding Identical Protein Binding Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gene Expression Axonemal A Tubule Inner Sheath Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasm Innate Immune Response PERK-mediated Unfolded Protein Response CHOP-ATF4 Complex Axonemal Microtubule DNA Deamination Chromatin RNA Metabolic Process Response To Radiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Signal Transduction By P53 Class Mediator Lewy Body Core Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Response To Light Stimulus Defense Response To Symbiont Regulation Of Fatty Acid Beta-oxidation Response To Interleukin-1 Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Translational Initiation	Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Translation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Nucleoplasm Positive Regulation Of Proteasomal Protein Catabolic Process Macromolecule Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Neuron Projection Organization MRNA Cleavage And Polyadenylation Specificity Factor Complex TOR Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Eukaryotic Translation Elongation Factor 1 Complex Regulation Of Cell Adhesion Mediated By Integrin Regulation Of TORC1 Signaling Regulation Of TOR Signaling Regulation Of Cellular Component Organization Response To Stress Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Kinase Binding Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Negative Regulation Of Developmental Process Hematopoietic Stem Cell Proliferation Protein Metabolic Process Potassium Channel Activator Activity RNA Metabolic Process Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process PML Body Phosphatidylinositol-3,4-bisphosphate Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process TORC1 Signaling Positive Regulation Of TORC1 Signaling Regulation Of Chromosome Organization Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Protein Modification By Small Protein Conjugation
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