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TRIB3 and RBM4
Number of citations of the paper that reports this interaction (PubMedID
18276110
)
0
Data Source:
BioGRID
(two hybrid)
TRIB3
RBM4
Description
tribbles pseudokinase 3
RNA binding motif protein 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Mitogen-activated Protein Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
Ubiquitin Ligase Activator Activity
Nucleic Acid Binding
RNA Binding
MRNA Binding
MRNA 3'-UTR Binding
Protein Binding
Zinc Ion Binding
Cyclin Binding
MiRNA Binding
Pre-mRNA Binding
Metal Ion Binding
Pre-mRNA Intronic Binding
Pre-mRNA Intronic Pyrimidine-rich Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Regulation Of Autophagy
Regulation Of D-glucose Transmembrane Transport
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Insulin Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Cap-independent Translational Initiation
IRES-dependent Translational Initiation Of Linear MRNA
RNA Processing
MRNA Processing
Circadian Rhythm
RNA Splicing
Regulation Of Gene Expression
Negative Regulation Of Translation
Cell Differentiation
Pancreas Development
Regulatory NcRNA-mediated Gene Silencing
Negative Regulation Of Translation In Response To Stress
Circadian Regulation Of Gene Expression
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Enteroendocrine Cell Differentiation
Glucose Homeostasis
Entrainment Of Circadian Clock By Photoperiod
Positive Regulation Of Translation
Negative Regulation Of Translational Initiation
Regulation Of Insulin Receptor Signaling Pathway
Response To Arsenic-containing Substance
Regulation Of Nucleocytoplasmic Transport
Positive Regulation Of Muscle Cell Differentiation
Circadian Regulation Of Translation
Pathways
PIP3 activates AKT signaling
Activation of AKT2
PPARA activates gene expression
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes
Drugs
Diseases
GWAS
Information processing speed (
21130836
)
Logical memory (delayed recall) (
29274321
)
Logical memory (immediate recall) (
29274321
)
Bipolar disorder (
21926972
)
Interacting Genes
100 interacting genes:
ACACA
AKAP8L
AKT1
AKT2
APOBEC3A
APOBEC3C
APP
ARMC7
ATF4
BAG3
BCL6
BFSP2
BMPR2
C21orf58
C22orf39
CBX8
CHAF1A
CLCNKA
COPS6
CTAG1A
CTAG1B
DDIT3
DPPA3
DTX2
EEF1G
EFEMP2
EPHB6
EXOSC5
FAAP20
FAM161A
FAM90A1
FBXO7
GDF9
GIT1
GLIS3
GPATCH2L
GRB2
HAT1
HDAC4
HLA-B
HNRNPF
HOXB5
HOXC8
IL16
INCA1
INO80B
IRX6
KANK2
KAT5
KLHL38
KRT26
LENG1
LMO2
LMO3
MDFI
MDM2
MISP
MYC
OIP5
OSTF1
PADI4
PARD6B
PCSK5
PITX2
PKNOX2
PML
PPP1R26
PRKAB2
PRMT5
PRR19
PSMA3
RBM4
RBM48
RELA
RIDA
RPGRIP1
RPSA
SAMD11
SAXO1
SAXO4
SCNM1
SETDB1
SHFL
SNRPC
SPAG8
SPG21
SUOX
TCF19
TEKT3
TEKT4
TLE5
TRIM55
TRIM63
TTC23
TWIST1
UBTD2
USP20
UTP23
ZNF417
ZNF587
97 interacting genes:
AQR
CCNA1
CDK2
DDX17
DDX5
DHX9
ESS2
HNRNPF
HNRNPH2
HNRNPH3
HNRNPK
HNRNPM
HNRNPUL1
KLHL41
LRP2BP
MAPK8IP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR10B
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR141
MIR143
MIR145
MIR155
MIR15B
MIR16-2
MIR17
MIR199A1
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
PABPC1
PRPF31
PTBP2
PTEN
RBM10
RBM22
RBM23
RBM42
RBM7
RNF10
SF1
SF3B4
SMAD5
SNRPC
STEEP1
SURF6
TRIB3
U2AF2
Entrez ID
57761
5936
HPRD ID
09836
03982
Ensembl ID
ENSG00000101255
ENSG00000173933
Uniprot IDs
B4DMM9
J3KR25
Q96RU7
Q9BWF3
PDB IDs
2DNQ
Enriched GO Terms of Interacting Partners
?
Nucleus
Protein Binding
Negative Regulation Of Gene Expression
DNA-binding Transcription Factor Binding
Identical Protein Binding
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
Axonemal A Tubule Inner Sheath
Negative Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytoplasm
Innate Immune Response
PERK-mediated Unfolded Protein Response
CHOP-ATF4 Complex
Axonemal Microtubule
DNA Deamination
Chromatin
RNA Metabolic Process
Response To Radiation
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Signal Transduction By P53 Class Mediator
Lewy Body Core
Regulation Of Apoptotic Signaling Pathway
Response To Growth Factor
Response To Light Stimulus
Defense Response To Symbiont
Regulation Of Fatty Acid Beta-oxidation
Response To Interleukin-1
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Translational Initiation
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
MRNA 3'-UTR Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Gene Expression
Extracellular Vesicle
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of MRNA Metabolic Process
Negative Regulation Of Translation
Positive Regulation Of MRNA Catabolic Process
MRNA Destabilization
RNA Destabilization
Negative Regulation Of Cell Migration
Regulation Of Metabolic Process
Negative Regulation Of Angiogenesis
Negative Regulation Of Cell Motility
Negative Regulation Of Vasculature Development
Regulation Of MRNA Stability
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Locomotion
Regulation Of Angiogenesis
Regulation Of Vasculature Development
Regulation Of RNA Stability
Negative Regulation Of Cytokine Production
Regulation Of Translation
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Protein Metabolic Process
Regulation Of Endothelial Cell Migration
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Developmental Process
Regulation Of Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
MRNA Splicing, Via Spliceosome
Negative Regulation Of Signal Transduction
RNA Splicing, Via Transesterification Reactions
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Cell Motility
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