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TRIB3 and RBM48
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
TRIB3
RBM48
Gene Name
tribbles pseudokinase 3
RNA binding motif protein 48
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Nucleoplasm
Molecular Function
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
RNA Binding
Biological Process
Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Glucose Transport
Positive Regulation Of Protein Binding
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Regulation Of MAP Kinase Activity
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Ubiquitin-protein Transferase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways
Signaling by the B Cell Receptor (BCR)
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
Activation of PKB
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
PI-3K cascade
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Signaling by VEGF
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Adaptive Immune System
PPARA activates gene expression
Costimulation by the CD28 family
Activation of PKB
PIP3 activates AKT signaling
IRS-mediated signalling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
PI3K events in ERBB2 signaling
VEGFR2 mediated vascular permeability
Downstream signaling of activated FGFR
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
NGF signalling via TRKA from the plasma membrane
Negative regulation of the PI3K/AKT network
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
PI3K Cascade
Drugs
Diseases
GWAS
Information processing speed (
21130836
)
Protein-Protein Interactions
21 interactors:
AKT1
AKT2
APP
ATF4
BMPR2
COPS6
DDIT3
EEF1G
GDF9
GIT1
HLA-B
HRSP12
KAT5
PRMT5
PSMA3
RBM4
RBM48
RELA
RPGRIP1
RPSA
SETDB1
50 interactors:
ANXA7
APLP1
BID
BTBD2
C11orf49
CCDC106
CDK5RAP2
CDKN1A
CDKN2C
COX17
ERH
FAM118B
FXYD6
GADD45G
GLYAT
GSE1
GSTO1
HSPB1
HSPB3
ID2
KPNA2
MAFG
MAP7D1
MLLT3
MNAT1
MPHOSPH6
NUDT21
OSGEP
PAFAH1B3
PCDHA4
PNP
PPP1R8
PRG2
PSMD11
RAB27A
RFC5
RPA2
SAT1
SERPINB9
SH3GL3
SMN1
SULT1E1
TAF9
TK1
TNFSF10
TRDMT1
TRIB3
VIM
WDR33
ZNF24
Entrez ID
57761
84060
HPRD ID
09836
13173
Ensembl ID
ENSG00000101255
ENSG00000127993
Uniprot IDs
J3KR25
Q96RU7
B4DGJ6
B7Z2K5
Q5RL73
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Gene Expression
Cellular Protein Metabolic Process
Response To External Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Translation
Viral Process
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Regulation Of Cell Cycle
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Stress
Positive Regulation Of Protein Phosphorylation
Regulation Of Gene Expression
Response To Nutrient Levels
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Radiation
Posttranscriptional Regulation Of Gene Expression
Response To Extracellular Stimulus
Signal Transduction
Peripheral Nervous System Myelin Maintenance
Positive Regulation Of Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Glycogen Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Cytokine Production
Regulation Of Lipid Transport
Negative Regulation Of Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Ion Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Signaling
RNA Metabolic Process
Regulation Of Fatty Acid Beta-oxidation
Apoptotic Process
Nitrogen Compound Metabolic Process
Mitotic Cell Cycle Phase Transition
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle Phase Transition
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Developmental Process
Response To Stimulus
Central Nervous System Development
MRNA Polyadenylation
Nucleoside Metabolic Process
Negative Regulation Of Transferase Activity
RNA Polyadenylation
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic Cell Cycle
Apoptotic Process
Transcription-coupled Nucleotide-excision Repair
Negative Regulation Of Kinase Activity
Regulation Of Cell Cycle Phase Transition
Response To Stress
Negative Regulation Of Catalytic Activity
Programmed Cell Death
Negative Regulation Of Cellular Protein Metabolic Process
Cell Death
Death
MRNA Processing
Multicellular Organismal Development
Xenobiotic Metabolic Process
Cellular Response To Xenobiotic Stimulus
Cellular Response To DNA Damage Stimulus
Response To Xenobiotic Stimulus
Regulation Of Cellular Protein Metabolic Process
Nervous System Development
Negative Regulation Of Protein Metabolic Process
Anatomical Structure Development
Mitotic Cell Cycle Process
Regulation Of Cell Cycle Process
Cellular Metabolic Process
Negative Regulation Of Protein Phosphorylation
Mitotic G1 DNA Damage Checkpoint
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Cellular Response To Stress
Positive Regulation Of Cell Cycle Arrest
Tagcloud
?
6weeks
amounts
atf
attenuation
caspase3
chop
db
diabetic
ebp
endoplasmic
glp
homolog
homologous
immunoblot
inhibiting
islets
nuclei
orally
promoted
promotes
reticulum
staining
tribbles
triggers
tunel
untreated
vildagliptin
vs
x10
Tagcloud (Difference)
?
6weeks
amounts
atf
attenuation
caspase3
chop
db
diabetic
ebp
endoplasmic
glp
homolog
homologous
immunoblot
inhibiting
islets
nuclei
orally
promoted
promotes
reticulum
staining
tribbles
triggers
tunel
untreated
vildagliptin
vs
x10
Tagcloud (Intersection)
?