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TRIB3 and SETDB1
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
TRIB3
SETDB1
Description
tribbles pseudokinase 3
SET domain bifurcated histone lysine methyltransferase 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Mitogen-activated Protein Kinase Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
Ubiquitin Ligase Activator Activity
DNA Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Transferase Activity
Histone Methyltransferase Activity
Metal Ion Binding
Histone H3K9 Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K9me2 Methyltransferase Activity
Histone H3K9 Monomethyltransferase Activity
Histone H3K9 Trimethyltransferase Activity
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Regulation Of Autophagy
Regulation Of D-glucose Transmembrane Transport
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Insulin Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
Negative Regulation Of Gene Expression
Methylation
Heterochromatin Organization
Transposable Element Silencing By Heterochromatin Formation
Pathways
PIP3 activates AKT signaling
Activation of AKT2
PPARA activates gene expression
Negative regulation of the PI3K/AKT network
CD28 dependent PI3K/Akt signaling
VEGFR2 mediated vascular permeability
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
PKMTs methylate histone lysines
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases
GWAS
Information processing speed (
21130836
)
Logical memory (delayed recall) (
29274321
)
Logical memory (immediate recall) (
29274321
)
Body mass index (
26426971
)
Caffeine consumption from coffee or tea (
33287642
)
Caffeine consumption from tea (
33287642
)
Chronic kidney disease (
20383146
)
Coffee consumption (
31046077
)
Cutaneous squamous cell carcinoma (
32041948
)
Hip circumference adjusted for BMI (
34021172
)
Melanoma (
21983785
)
Neurological blood protein biomarker levels (
31320639
)
Nevus count or cutaneous melanoma (
30429480
)
Interacting Genes
100 interacting genes:
ACACA
AKAP8L
AKT1
AKT2
APOBEC3A
APOBEC3C
APP
ARMC7
ATF4
BAG3
BCL6
BFSP2
BMPR2
C21orf58
C22orf39
CBX8
CHAF1A
CLCNKA
COPS6
CTAG1A
CTAG1B
DDIT3
DPPA3
DTX2
EEF1G
EFEMP2
EPHB6
EXOSC5
FAAP20
FAM161A
FAM90A1
FBXO7
GDF9
GIT1
GLIS3
GPATCH2L
GRB2
HAT1
HDAC4
HLA-B
HNRNPF
HOXB5
HOXC8
IL16
INCA1
INO80B
IRX6
KANK2
KAT5
KLHL38
KRT26
LENG1
LMO2
LMO3
MDFI
MDM2
MISP
MYC
OIP5
OSTF1
PADI4
PARD6B
PCSK5
PITX2
PKNOX2
PML
PPP1R26
PRKAB2
PRMT5
PRR19
PSMA3
RBM4
RBM48
RELA
RIDA
RPGRIP1
RPSA
SAMD11
SAXO1
SAXO4
SCNM1
SETDB1
SHFL
SNRPC
SPAG8
SPG21
SUOX
TCF19
TEKT3
TEKT4
TLE5
TRIM55
TRIM63
TTC23
TWIST1
UBTD2
USP20
UTP23
ZNF417
ZNF587
110 interacting genes:
AIFM1
AKT1
ANXA7
APC
APLP1
ASAH1
ATF7IP
ATF7IP2
BAG6
BARD1
BHLHE40
BID
BRIX1
BTBD2
BTG3
CBX8
CCDC106
CDK4
CDKN1A
CFAP68
CLSTN1
CREBBP
CRELD1
DAP
DLEU1
DNMT3A
ECSIT
ERG
ERH
FAM118B
FLYWCH1
GIPC2
GPS2
GRB7
GSTO1
H3-4
H3C1
H3C15
H4C16
HDAC1
HDAC2
HMOX2
HSPB3
JARID2
KDM1A
LRIF1
LUC7L2
MAD2L1BP
MAP4K5
MBD1
MDM2
MOB4
MRPL44
MZT2B
NIPSNAP3A
OLFML3
ORAI2
PABPC4
PAFAH1B3
PCDHA4
PCYT2
PGAM5
PHF10
PIAS4
PLEKHA4
POLA2
PPA1
PPP1R8
PRKRA
PSMD11
PSME1
PTPRS
QTRT1
RIF1
RNF10
S100A10
SAT1
SERPINB9
SIN3A
SIN3B
SKIL
SLC38A3
SMN1
SNIP1
SUFU
SULT1E1
SUMO2
TARDBP
TCERG1
THAP8
TK1
TOB1
TOLLIP
TPI1
TRBV2
TRDMT1
TRIB3
TRIM16
TRIM28
TRIP6
TSC22D1
TTR
TXNDC9
UBE2I
ULK2
USP11
VHL
VIM
ZFP64
ZNF24
Entrez ID
57761
9869
HPRD ID
09836
06828
Ensembl ID
ENSG00000101255
ENSG00000143379
Uniprot IDs
B4DMM9
J3KR25
Q96RU7
A0A8I5KT93
Q15047
X6R732
PDB IDs
3DLM
4X3S
5KCH
5KCO
5KE2
5KE3
5KH6
5QT1
5QT2
6AU2
6AU3
6BHD
6BHE
6BHG
6BHH
6BHI
6BPI
7C9N
7CAJ
7CD9
7CJT
8G5E
8IYA
8UWP
9CUW
9CUX
Enriched GO Terms of Interacting Partners
?
Nucleus
Protein Binding
Negative Regulation Of Gene Expression
DNA-binding Transcription Factor Binding
Identical Protein Binding
Chromatin Remodeling
Chromatin Organization
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
Axonemal A Tubule Inner Sheath
Negative Regulation Of DNA-templated Transcription
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Cytoplasm
Innate Immune Response
PERK-mediated Unfolded Protein Response
CHOP-ATF4 Complex
Axonemal Microtubule
DNA Deamination
Chromatin
RNA Metabolic Process
Response To Radiation
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Macromolecule Metabolic Process
Negative Regulation Of Gene Expression, Epigenetic
Regulation Of Signal Transduction By P53 Class Mediator
Lewy Body Core
Regulation Of Apoptotic Signaling Pathway
Response To Growth Factor
Response To Light Stimulus
Defense Response To Symbiont
Regulation Of Fatty Acid Beta-oxidation
Response To Interleukin-1
Regulation Of Intrinsic Apoptotic Signaling Pathway
Regulation Of Generation Of Precursor Metabolites And Energy
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Translational Initiation
Transcription Corepressor Activity
Nucleus
Nucleoplasm
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Heterochromatin Formation
Negative Regulation Of Gene Expression, Epigenetic
SUMO Transferase Activity
Regulation Of RNA Metabolic Process
Chromatin Remodeling
Epigenetic Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Cellular Response To Stress
Chromatin Organization
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Transcription Coregulator Activity
Constitutive Heterochromatin Formation
Cytoplasm
MRF Binding
Chromatin Binding
Transcription Regulator Complex
DNA Methylation-dependent Constitutive Heterochromatin Formation
Ubiquitin Protein Ligase Binding
Sin3-type Complex
Regulation Of Mitotic Cell Cycle Phase Transition
Heterochromatin
Protein Sumoylation
Nuclear Matrix
Nuclear Body
RNA Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Proteolysis
Krueppel-associated Box Domain Binding
Enzyme Binding
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