TRIB3 and CLCNKA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIB3	CLCNKA
Description		tribbles pseudokinase 3	chloride voltage-gated channel Ka
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex
	Molecular Function	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity Ubiquitin Ligase Activator Activity	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Chloride Transmembrane Transporter Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Autophagy Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Insulin Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress	Monoatomic Ion Transport Chloride Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport Renal Absorption Chloride Transmembrane Transport
Pathways		PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Stimuli-sensing channels
Drugs			Niflumic acid Talniflumate
Diseases			Bartter syndrome
GWAS		Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular ejection fraction ( 32382064 33495596) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		100 interacting genes: ACACA AKAP8L AKT1 AKT2 APOBEC3A APOBEC3C APP ARMC7 ATF4 BAG3 BCL6 BFSP2 BMPR2 C21orf58 C22orf39 CBX8 CHAF1A CLCNKA COPS6 CTAG1A CTAG1B DDIT3 DPPA3 DTX2 EEF1G EFEMP2 EPHB6 EXOSC5 FAAP20 FAM161A FAM90A1 FBXO7 GDF9 GIT1 GLIS3 GPATCH2L GRB2 HAT1 HDAC4 HLA-B HNRNPF HOXB5 HOXC8 IL16 INCA1 INO80B IRX6 KANK2 KAT5 KLHL38 KRT26 LENG1 LMO2 LMO3 MDFI MDM2 MISP MYC OIP5 OSTF1 PADI4 PARD6B PCSK5 PITX2 PKNOX2 PML PPP1R26 PRKAB2 PRMT5 PRR19 PSMA3 RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SAMD11 SAXO1 SAXO4 SCNM1 SETDB1 SHFL SNRPC SPAG8 SPG21 SUOX TCF19 TEKT3 TEKT4 TLE5 TRIM55 TRIM63 TTC23 TWIST1 UBTD2 USP20 UTP23 ZNF417 ZNF587	22 interacting genes: CYSRT1 IKZF3 KLHL20 KPRP KRT31 KRT34 KRT37 KRT39 KRTAP21-2 KRTAP4-12 KRTAP6-3 LHX3 MBD3L1 PBX4 SLITRK5 SPMIP4 SRPK2 TCF12 TCF4 TEPSIN TRIB3 ZNF511
Entrez ID		57761	1187
HPRD ID		09836	03608
Ensembl ID		ENSG00000101255	ENSG00000186510
Uniprot IDs		B4DMM9 J3KR25 Q96RU7	P51800
PDB IDs			2PFI
Enriched GO Terms of Interacting Partners?		Nucleus Protein Binding Negative Regulation Of Gene Expression DNA-binding Transcription Factor Binding Identical Protein Binding Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Epigenetic Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Regulation Of Gene Expression Axonemal A Tubule Inner Sheath Negative Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasm Innate Immune Response PERK-mediated Unfolded Protein Response CHOP-ATF4 Complex Axonemal Microtubule DNA Deamination Chromatin RNA Metabolic Process Response To Radiation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Signal Transduction By P53 Class Mediator Lewy Body Core Regulation Of Apoptotic Signaling Pathway Response To Growth Factor Response To Light Stimulus Defense Response To Symbiont Regulation Of Fatty Acid Beta-oxidation Response To Interleukin-1 Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Defense Response To Other Organism Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Translational Initiation	Intermediate Filament Keratin Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epidermis Development Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Establishment Of Skin Barrier DNA-binding Transcription Factor Activity Type II Interferon Binding Coated Vesicle Membrane Skin Epidermis Development Cellular Developmental Process Tissue Morphogenesis Cell Differentiation Anatomical Structure Morphogenesis Tissue Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Skin Development E-box Binding Medial Motor Column Neuron Differentiation Prolactin Secreting Cell Differentiation Regulation Of Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Protein K33-linked Ubiquitination
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