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TRIB3 and HLA-B
Number of citations of the paper that reports this interaction (PMID
18276110
)
7
Data Source:
BioGRID
(two hybrid)
TRIB3
HLA-B
Gene Name
tribbles pseudokinase 3
major histocompatibility complex, class I, B
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Golgi Membrane
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Membrane
Integral Component Of Membrane
Phagocytic Vesicle Membrane
Early Endosome Membrane
MHC Class I Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Transcription Corepressor Activity
Protein Kinase Inhibitor Activity
Protein Binding
ATP Binding
Kinase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-protein Transferase Regulator Activity
Receptor Binding
Peptide Antigen Binding
TAP Binding
Chaperone Binding
Biological Process
Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Glucose Transport
Positive Regulation Of Protein Binding
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Regulation Of MAP Kinase Activity
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Innate Immune Response
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Ubiquitin-protein Transferase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Positive Regulation Of T Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent
Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent
Regulation Of T Cell Anergy
Defense Response
Immune Response
Viral Process
Detection Of Bacterium
Cytokine-mediated Signaling Pathway
Regulation Of Interleukin-12 Production
Regulation Of Interleukin-6 Production
Protection From Natural Killer Cell Mediated Cytotoxicity
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Innate Immune Response
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Regulation Of Dendritic Cell Differentiation
Pathways
Signaling by the B Cell Receptor (BCR)
Metabolism of lipids and lipoproteins
Signaling by FGFR in disease
Activation of PKB
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
DAP12 signaling
Downstream signaling events of B Cell Receptor (BCR)
PI3K/AKT activation
PI-3K cascade
PI3K Cascade
Signaling by PDGF
DAP12 interactions
GAB1 signalosome
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
Signaling by VEGF
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
PI3K/AKT Signaling in Cancer
Adaptive Immune System
PPARA activates gene expression
Costimulation by the CD28 family
Activation of PKB
PIP3 activates AKT signaling
IRS-mediated signalling
IGF1R signaling cascade
VEGFA-VEGFR2 Pathway
IRS-related events triggered by IGF1R
PI3K events in ERBB2 signaling
VEGFR2 mediated vascular permeability
Downstream signaling of activated FGFR
Signaling by Insulin receptor
Innate Immune System
Signalling by NGF
Fatty acid, triacylglycerol, and ketone body metabolism
Insulin receptor signalling cascade
Signaling by Ligand-Responsive EGFR Variants in Cancer
IRS-related events
NGF signalling via TRKA from the plasma membrane
Negative regulation of the PI3K/AKT network
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by FGFR
IRS-mediated signalling
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
PI3K Cascade
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Interferon gamma signaling
Interferon Signaling
Endosomal/Vacuolar pathway
Cytokine Signaling in Immune system
Interferon alpha/beta signaling
Class I MHC mediated antigen processing & presentation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
ER-Phagosome pathway
Adaptive Immune System
Drugs
Diseases
GWAS
Information processing speed (
21130836
)
Ankylosing spondylitis (
21743469
)
Beta-2 microglubulin plasma levels (
23417110
)
CD4:CD8 lymphocyte ratio (
20045101
)
Cervical cancer (
23482656
)
Drug-induced liver injury (flucloxacillin) (
19483685
)
Epstein-Barr virus immune response (EBNA-1) (
23326239
)
Graves' disease (
21841780
)
Height (
19343178
23563607
)
HIV-1 control (
20205591
21051598
20041166
)
Hypothyroidism (
22493691
)
Multiple sclerosis (
22190364
19525953
)
Nasopharyngeal carcinoma (
20512145
)
Platelet counts (
22139419
)
Visceral adipose tissue adjusted for BMI (
22589738
)
Vitiligo (
20526339
)
White blood cell count (
21738480
)
Protein-Protein Interactions
21 interactors:
AKT1
AKT2
APP
ATF4
BMPR2
COPS6
DDIT3
EEF1G
GDF9
GIT1
HLA-B
HRSP12
KAT5
PRMT5
PSMA3
RBM4
RBM48
RELA
RPGRIP1
RPSA
SETDB1
16 interactors:
ARHGEF4
ATF7IP
B2M
CD8A
CSF1
KIR3DL1
KIR3DS1
KLRD1
LILRB1
LILRB2
MAGEA1
SRC
STAT1
TRA
TRB
TRIB3
Entrez ID
57761
3106
HPRD ID
09836
00828
Ensembl ID
ENSG00000101255
ENSG00000234745
Uniprot IDs
J3KR25
Q96RU7
E5FQ95
P01889
P30466
S6AU73
PDB IDs
3VCL
4JQV
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Gene Expression
Cellular Protein Metabolic Process
Response To External Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Protein Metabolic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Translation
Viral Process
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Regulation Of Cell Cycle
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Phosphorylation
Cellular Response To Stress
Positive Regulation Of Protein Phosphorylation
Regulation Of Gene Expression
Response To Nutrient Levels
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Response To Radiation
Posttranscriptional Regulation Of Gene Expression
Response To Extracellular Stimulus
Signal Transduction
Peripheral Nervous System Myelin Maintenance
Positive Regulation Of Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Glycogen Biosynthetic Process
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Cytokine Production
Regulation Of Lipid Transport
Negative Regulation Of Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Ion Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Signaling
RNA Metabolic Process
Regulation Of Fatty Acid Beta-oxidation
Apoptotic Process
Immune Response
Regulation Of Immune Response
Regulation Of Immune System Process
Defense Response
Immune System Process
Innate Immune Response
Leukocyte Differentiation
Response To Molecule Of Bacterial Origin
Cell Activation
Cellular Response To Lipopolysaccharide
Response To Other Organism
Fc Receptor Mediated Inhibitory Signaling Pathway
Cellular Response To Molecule Of Bacterial Origin
Response To Biotic Stimulus
Response To Stress
Immune Response-inhibiting Cell Surface Receptor Signaling Pathway
Response To Bacterium
Immune Response-inhibiting Signal Transduction
Leukocyte Activation
Single Organismal Cell-cell Adhesion
Regulation Of Dendritic Cell Differentiation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Virus
Hemopoiesis
Signaling
Response To Lipopolysaccharide
Cell Communication
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune System Development
Cellular Response To Organic Substance
Positive Regulation Of Cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Process
Lymphocyte Activation
Cellular Response To Lipid
Defense Response To Virus
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Positive Regulation Of Immune System Process
Response To Stimulus
Immune Response-regulating Signaling Pathway
Tissue Homeostasis
Negative Regulation Of Cell Adhesion
Viral Process
Positive Regulation Of T Cell Activation
Cellular Response To Insulin Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud
?
6weeks
amounts
atf
attenuation
caspase3
chop
db
diabetic
ebp
endoplasmic
glp
homolog
homologous
immunoblot
inhibiting
islets
nuclei
orally
promoted
promotes
reticulum
staining
tribbles
triggers
tunel
untreated
vildagliptin
vs
x10
Tagcloud (Difference)
?
6weeks
amounts
atf
attenuation
caspase3
chop
db
diabetic
ebp
endoplasmic
glp
homolog
homologous
immunoblot
inhibiting
islets
nuclei
orally
promoted
promotes
reticulum
staining
tribbles
triggers
tunel
untreated
vildagliptin
vs
x10
Tagcloud (Intersection)
?