NCF1 and MGAM

Number of citations of the paper that reports this interaction (PubMedID 16052631)
0

Data Source:
BioGRID (two hybrid)

		NCF1	MGAM
Description		neutrophil cytosolic factor 1	maltase-glucoamylase
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Lipid Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Catalytic Activity Glucan 1,4-alpha-glucosidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Oligo-1,6-glucosidase Activity Protein Binding Amylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Response To Yeast Leukocyte Mediated Cytotoxicity Respiratory Burst Involved In Defense Response Protein Targeting To Membrane Leukotriene Metabolic Process Superoxide Metabolic Process Inflammatory Response Cellular Defense Response Response To Bacterium Superoxide Anion Generation Defense Response To Bacterium Innate Immune Response Respiratory Burst Hydrogen Peroxide Biosynthetic Process Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Defense Response To Fungus Regulation Of Respiratory Burst Involved In Inflammatory Response Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Fungus Cellular Response To Glucose Stimulus Cellular Response To Testosterone Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process	Maltose Catabolic Process Carbohydrate Metabolic Process Starch Catabolic Process Disaccharide Catabolic Process Dextrin Catabolic Process
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle	Digestion of dietary carbohydrate Neutrophil degranulation
Drugs		Dextromethorphan	Acarbose Miglitol Voglibose
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Systemic lupus erythematosus ( 33493351)	1,5-anhydroglucitol levels ( 28588231) Anorexia nervosa ( 23568457) Idiopathic dilated cardiomyopathy ( 29495422)
Interacting Genes		29 interacting genes: ACTB CEBPA CSNK2B FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN RB1 SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9	7 interacting genes: AQP6 CPLX4 CREB3L1 GPR42 NCF1 SLC18A1 TMEM14B
Entrez ID		653361	8972
HPRD ID			01104
Ensembl ID		ENSG00000158517	ENSG00000257335
Uniprot IDs		P14598	O43451
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP 7YXW 8WEJ	2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Signaling Enzyme Binding Superoxide-generating NADPH Oxidase Activator Activity Regulation Of Immune System Process Cytosol Protein Phosphorylation Protein Domain Specific Binding Regulation Of Protein Metabolic Process Phosphorylation Maltose Metabolic Process NADPH Oxidase Complex Histone H3T6 Kinase Activity Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Regulation Of Hemopoiesis Regulation Of G1/S Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Activation Alpha-1,4-glucosidase Activity Superoxide Anion Generation Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Apoptotic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Positive Regulation Of Leukocyte Differentiation Alpha-glucosidase Activity Phagolysosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Multicellular Organismal Process Protein Serine Kinase Activity Rb-E2F Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Primary Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport Regulation Of Cell Development Superoxide Metabolic Process Plasma Membrane Extracellular Exosome Response To Hormone Nuclear Matrix Regulation Of Multicellular Organismal Development	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Vesicle-mediated Transport In Synapse Erythrocyte Apoptotic Process Neurotransmitter Transport Terminal Bouton Aminergic Neurotransmitter Loading Into Synaptic Vesicle Neutrophil-mediated Killing Of Fungus Monoatomic Anion Channel Activity Carbon Dioxide Transmembrane Transporter Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Carbon Dioxide Transmembrane Transport Thioesterase Binding Positive Regulation Of Keratinocyte Migration Presynapse Maintenance Of Postsynaptic Specialization Structure Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Protein Localization To Cleavage Furrow Positive Regulation Of Focal Adhesion Disassembly Cellular Response To Bacterial Lipopeptide Maintenance Of Postsynaptic Density Structure Monoamine:proton Antiporter Activity Serotonin Uptake Amine Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Serotonin:sodium:chloride Symporter Activity Catecholamine Uptake Dopamine Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Norepinephrine Uptake Neurotransmitter Loading Into Synaptic Vesicle Extracellular Matrix Constituent Secretion Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Bacterium Respiratory Burst Involved In Defense Response Phagolysosome Hydrogen Peroxide Biosynthetic Process Cellular Response To Testosterone Stimulus Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response Superoxide-generating NADPH Oxidase Activator Activity
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