MIB1 and UBE2D4

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		MIB1	UBE2D4
Gene Name		mindbomb E3 ubiquitin protein ligase 1	ubiquitin-conjugating enzyme E2D 4 (putative)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: AZI2 BLM CEP131 DAB2 DAPK1 SNX5 TBK1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	90 interactors: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 LRSAM1 MAGEA11 MAP3K1 MARCH3 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF26 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBE4A UBOX5 UBTD1 UFM1 UHRF2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		57534	51619
HPRD ID		06660	14242
Ensembl ID		ENSG00000101752	ENSG00000078967
Uniprot IDs		Q86YT6	Q9Y2X8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Dendritic Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune System Process Cellular Response To Stress Protein Catabolic Process Response To Stress Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process DNA Double-strand Break Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process DNA Repair Pinocytosis Positive Regulation Of Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Catabolic Process Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Defense Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Cellular Response To Stimulus	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Viral Entry Into Host Cell Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Metabolic Process Negative Regulation Of Viral Process Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Viral Transcription Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Regulation Of Signal Transduction Innate Immune Response Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Interferon-gamma Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Interferon-gamma Programmed Cell Death Cell Death Death Histone Monoubiquitination
Tagcloud ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Difference) ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken	accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination
Tagcloud (Intersection) ?