MIB1 and RIPK4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		MIB1	RIPK4
Description		MIB E3 ubiquitin protein ligase 1	receptor interacting serine/threonine kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Morphogenesis Of An Epithelium Skin Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)	Femur bone mineral density x serum urate levels interaction ( 34046847) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN	38 interacting genes: ANK2 ANK3 ANKRD6 ASB3 BIRC2 BIRC3 BTRC CARS2 CLTC CTBP1 FBXW11 GPSM3 HSPA5 KPNA1 LINC01537 MACF1 MAGI2 MIB1 MICU1 MTPN MYO1E NAPA PADI2 PREPL PRKCB PRKCD PTPRK RPL13 SPAG8 SPAST STAM TNPO2 TRAF7 UBE4B VCP VWC2L WDR19 XIAP
Entrez ID		57534	54101
HPRD ID		06660	10419
Ensembl ID		ENSG00000101752	ENSG00000183421
Uniprot IDs		Q86YT6	Q96T11 Q9H4D1
PDB IDs		4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination	Cytoplasm Canonical NF-kappaB Signal Transduction Cellular Localization Signal Transduction Vesicle-mediated Transport Intracellular Protein Localization Protein Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Intracellular Signaling Cassette Establishment Of Protein Localization Ubiquitin Protein Ligase Activity Mitotic Spindle Disassembly Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Protein Kinase C Signaling Golgi Vesicle Transport Protein Polyubiquitination Intracellular Transport Regulation Of Cell Communication Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Protein Localization To Membrane Positive Regulation Of Protein Metabolic Process Protein Metabolic Process Golgi To Plasma Membrane Protein Transport Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Ubiquitination Channel Activator Activity Proteolysis Involved In Protein Catabolic Process Protein Localization To Cell Periphery Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Intracellular Protein Transport Negative Regulation Of Signal Transduction Regulation Of Post-translational Protein Modification Cytosol Ubiquitin-dependent Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Modification-dependent Protein Catabolic Process Cytoskeleton Positive Regulation Of Membrane Potential Establishment Of Protein Localization To Plasma Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?