MIB1 and EPB41L4A

Number of citations of the paper that reports this interaction (PubMedID 27510968)
67

Data Source:
BioGRID (two hybrid)

		MIB1	EPB41L4A
Description		MIB E3 ubiquitin protein ligase 1	erythrocyte membrane protein band 4.1 like 4A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse	Cytoplasm Cytoskeleton Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Cytoskeletal Protein Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Actomyosin Structure Organization
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)	Common carotid intima-media thickness in HIV negative individuals ( 29206233) Night sleep phenotypes ( 27126917) Refractive error ( 32231278) Suicide ideation score in major depressive disorder ( 26079190) Thyroid cancer ( 28195142) vWF and FVIII levels ( 21810271)
Interacting Genes		17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN	5 interacting genes: APP MIB1 SRPK1 SRPK2 TNS2
Entrez ID		57534	64097
HPRD ID		06660	09939
Ensembl ID		ENSG00000101752	ENSG00000129595
Uniprot IDs		Q86YT6	Q8N8X1 Q8NEH8 Q9HCS5
PDB IDs		4TSE 4XI6 4XI7 4XIB 8V0D 8V0E
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination	Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Neuron Apoptotic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Viral Genome Replication Regulation Of MRNA Metabolic Process Spliceosomal Complex Assembly Negative Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Viral Genome Replication RNA Exonuclease Activity, Producing 5'-phosphomonoesters Acetylcholine Receptor Activator Activity PTB Domain Binding Innate Immune Response Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Protein Metabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Modification Process Regulation Of MRNA Processing Regulation Of Viral Life Cycle MRNA Metabolic Process Regulation Of Viral Process Regulation Of MRNA Splicing, Via Spliceosome Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endocytosis Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Nuclear Speck Organization 5'-3' RNA Exonuclease Activity Intermediate-density Lipoprotein Particle Defense Response To Symbiont Axon Midline Choice Point Recognition Defense Response To Other Organism Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding
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