UBE2D4 and UVSSA

Number of citations of the paper that reports this interaction (PubMedID 29323787)
0

Data Source:
BioGRID (enzymatic study)

		UBE2D4	UVSSA
Description		ubiquitin conjugating enzyme E2 D4	UV stimulated scaffold protein A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Chromosome Site Of DNA Damage
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Chromatin-protein Adaptor Activity RNA Polymerase Inhibitor Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	DNA Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization DNA Damage Response Response To UV Protein Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Chronotype ( 30696823)
Interacting Genes		111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	8 interacting genes: ERCC8 KPNA3 MAGEA4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1
Entrez ID		51619	57654
HPRD ID		14242	17216
Ensembl ID		ENSG00000078967	ENSG00000163945
Uniprot IDs		Q9Y2X8	A0A7I2V4K1 Q2YD98
PDB IDs			5XV8 7OO3 7OOP 7OPC 7OPD 8B3D 8B3G 8QH5 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Proteolysis Protein Autoubiquitination Protein Modification Process Catabolic Process Protein K6-linked Ubiquitination Protein K11-linked Ubiquitination ATP Binding Protein Monoubiquitination Nucleus Regulation Of Transcription-coupled Nucleotide-excision Repair Nucleotide Binding Negative Regulation Of BMP Signaling Pathway Ubiquitin Protein Ligase Activity Transferase Activity Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Viral Penetration Into Host Nucleus ISG15 Transferase Activity Protein Catabolic Process Nucleoplasm Nucleotide-excision Repair Complex Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Intracellular Transport Of Virus Protein-containing Complex Host Cell NLS-dependent Protein Nuclear Import Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Protein K29-linked Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein K27-linked Ubiquitination
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