UBE2D4 and RLIM

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2D4	RLIM
Gene Name		ubiquitin-conjugating enzyme E2D 4 (putative)	ring finger protein, LIM domain interacting
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Transcriptional Repressor Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Random Inactivation Of X Chromosome
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		90 interactors: AMFR ARIH2 BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 INCA1 LRSAM1 MAGEA11 MAP3K1 MARCH3 MGRN1 MIB1 MID1 MID2 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 RBCK1 RCHY1 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF165 RNF166 RNF167 RNF181 RNF185 RNF2 RNF25 RNF26 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM8 UBE4A UBOX5 UBTD1 UFM1 UHRF2 XIAP ZNRF1 ZNRF2 ZNRF4	27 interactors: ESR1 ISL1 LDB1 LDB2 LHX1 LHX2 LHX3 LIMK1 LMO2 LNX2 PDLIM1 REXO1 RPS14 SIN3A SMURF2 SNX17 SS18L1 STAT6 STMN1 TERF1 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2
Entrez ID		51619	51132
HPRD ID		14242	02304
Ensembl ID		ENSG00000078967	ENSG00000131263
Uniprot IDs		Q9Y2X8	Q9NVW2
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Protein Polyubiquitination Protein Autoubiquitination Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Regulation Of Viral Entry Into Host Cell Protein K48-linked Ubiquitination Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Metabolic Process Negative Regulation Of Viral Process Catabolic Process Proteolysis Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Negative Regulation Of Viral Transcription Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Process Regulation Of Signal Transduction Innate Immune Response Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Interferon-gamma Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Apoptotic Process Response To Interferon-gamma Programmed Cell Death Cell Death Death Histone Monoubiquitination	Protein K48-linked Ubiquitination Protein Polyubiquitination Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Activation Of Innate Immune Response Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Innate Immune Response RNA Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Protein K11-linked Ubiquitination Negative Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stimulus Positive Regulation Of Immune Response Gene Expression Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Ubiquitination Regulation Of Immune System Process Regulation Of Innate Immune Response System Development Mitotic Spindle Assembly Checkpoint
Tagcloud ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury p53 promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering p53 physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Difference) ?		accumulation apoptosis apoptotic arsenic cadmium conjugating degradation downregulation elevated enzymes family hand induce inorganic mercury promote proteasomal proximal rat suppressed suppression tubular ubiquitin ubiquitination	activators acts clim coactivator deacetylase embryonic encoded enlarge exerts hdac homeodomain inactivation inducer interacts interfering physically playing prevents recruiting repressed repression repressor s1 s4 sin3a sp1 tried
Tagcloud (Intersection) ?		p53