MIB1 and DAB2

Number of citations of the paper that reports this interaction (PMID 11812785)
24

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		MIB1	DAB2
Gene Name		mindbomb E3 ubiquitin protein ligase 1	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle	Nucleolus Lysosomal Membrane Plasma Membrane Coated Pit Focal Adhesion Apical Plasma Membrane Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Transforming Growth Factor Beta Receptor Homodimeric Complex Extracellular Vesicular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Integrin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Cargo Receptor Activity SMAD Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Cell Morphogenesis Involved In Differentiation In Utero Embryonic Development Positive Regulation Of Receptor Recycling Positive Regulation Of Protein Phosphorylation Receptor-mediated Endocytosis Pinocytosis Apoptotic Process Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Endoderm Development Excretion Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Protein Transport Wnt Signaling Pathway Myeloid Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Leading Edge Cell Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Endocytosis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Clathrin Coat Assembly Positive Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Androgen Receptor Signaling Pathway Membrane Organization Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Constitutive Signaling by NOTCH1 HD Domain Mutants Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH NOTCH2 Activation and Transmission of Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Signaling by NOTCH2 Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Formation of annular gap junctions Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS			Chronic kidney disease ( 20383146) Pancreatic cancer ( 22158540) Urate levels ( 23263486)
Protein-Protein Interactions		14 interactors: AZI2 BLM CEP131 DAB2 DAPK1 SNX5 TBK1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W	37 interactors: AP2M1 APLP1 APLP2 APP ATXN1L AXIN1 CDC16 CDK1 CSK DAB2IP DIP2A DVL1 DVL3 DYT10 FCHO2 FGR GRB2 INPP5D ITGB3 ITGB5 ITSN1 LDLR LRP1 LRP2 MIB1 MYO6 NECAP1 PIN1 PRKCB PRKCD PRKCG SMAD2 SMAD3 SMURF2 SRC TGFBR1 TGFBR2
Entrez ID		57534	1601
HPRD ID		06660	03139
Ensembl ID		ENSG00000101752	ENSG00000153071
Uniprot IDs		Q86YT6	B2RAW0 P98082
PDB IDs			2LSW
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Protein K48-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Dendritic Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune System Process Cellular Response To Stress Protein Catabolic Process Response To Stress Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process DNA Double-strand Break Processing Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process DNA Repair Pinocytosis Positive Regulation Of Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Catabolic Process Type I Interferon Production Cellular Response To Oxygen Levels Cellular Response To Organic Substance Immune Response Regulation Of Immune System Process Defense Response Cellular Response To DNA Damage Stimulus Regulation Of Immune Response Cellular Response To Stimulus	Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Signal Transduction Regulation Of Phosphorus Metabolic Process Negative Regulation Of Signal Transduction Signaling Cell Communication Regulation Of Signaling Negative Regulation Of Signaling Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Developmental Process Positive Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Anatomical Structure Morphogenesis Multicellular Organismal Development Wound Healing Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Vesicle-mediated Transport Positive Regulation Of Catalytic Activity Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Nervous System Development Embryonic Morphogenesis System Development Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Response To Stimulus Negative Regulation Of Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Immune System Process Anatomical Structure Development Platelet Activation
Tagcloud ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Difference) ?		atypical basal biotinylated cervical condylomas contribution counted counting dysplasia fields figures hpfs hpv immunohistochemically intensely layers make mfs mitotic parabasal probes progress proliferative rarely reach seen stained suprabasal undertaken	associations blotting ccnd1 ccnd2 dact1 day detect displayed expressions fosl1 increasing jun mean pathway pcr placenta play promoting real relationship signaling spss target tissue tissues trend value western wnt
Tagcloud (Intersection) ?