UBE2D4 and TRIM43

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2D4	TRIM43
Description		ubiquitin conjugating enzyme E2 D4	tripartite motif containing 43
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Centrosome Cytoskeleton
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Regulation Of Gene Expression Innate Immune Response
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Interacting Genes		111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	11 interacting genes: ENOX1 GRB7 MYOG TRIM27 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G2 UBE2K
Entrez ID		51619	129868
HPRD ID		14242	15560
Ensembl ID		ENSG00000078967	ENSG00000144015
Uniprot IDs		Q9Y2X8	Q96BQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Transferase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K63-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Protein Metabolic Process Regulation Of Viral Transcription ATP Binding Cellular Response To Interferon-beta Protein K6-linked Ubiquitination Response To Interferon-beta Protein K11-linked Ubiquitination Nucleotide Binding Catabolic Process Negative Regulation Of BMP Signaling Pathway Protein Autoubiquitination Negative Regulation Of Viral Process Positive Regulation Of Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Ultradian Rhythm Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Cellular Response To Cytokine Stimulus PML Body Regulation Of BMP Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Proteasomal Protein Catabolic Process Regulation Of Viral Process Response To Cytokine Free Ubiquitin Chain Polymerization Response To Denervation Involved In Regulation Of Muscle Adaptation Striated Muscle Atrophy Phosphatidylinositol 3-kinase Inhibitor Activity Response To Peptide Response To Muscle Inactivity Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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