UBE2D4 and MGRN1

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2D4	MGRN1
Description		ubiquitin conjugating enzyme E2 D4	mahogunin ring finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Ubiquitin Ligase Complex Nucleus Cytoplasm Endosome Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Protein Polyubiquitination Protein Monoubiquitination Smoothened Signaling Pathway Heart Development Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Protein-containing Complex Assembly Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Milk allergy (maternal genetic effects) ( 29489655) Triglyceride levels ( 32154731)
Interacting Genes		111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	13 interacting genes: AMFR TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W
Entrez ID		51619	23295
HPRD ID		14242	07397
Ensembl ID		ENSG00000078967	ENSG00000102858
Uniprot IDs		Q9Y2X8	O60291
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Modification Process Transferase Activity Catabolic Process ATP Binding Protein K6-linked Ubiquitination Protein Metabolic Process Protein K11-linked Ubiquitination Nucleotide Binding Protein Monoubiquitination Protein Autoubiquitination Protein K27-linked Ubiquitination Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein K29-linked Ubiquitination ERAD Pathway Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Regulation Of Establishment Of Protein Localization Regulation Of Protein Targeting To Mitochondrion Cellular Response To Stress Response To Endoplasmic Reticulum Stress SUMO Conjugating Enzyme Activity Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of BMP Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Ubiquitin-dependent Endocytosis Positive Regulation Of Establishment Of Protein Localization TOR Signaling Negative Regulation Of TOR Signaling Positive Regulation Of Viral Budding Via Host ESCRT Complex RING-like Zinc Finger Domain Binding Regulation Of TORC1 Signaling
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