UBE2D4 and DTX3L

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2D4	DTX3L
Description		ubiquitin conjugating enzyme E2 D4	deltex E3 ubiquitin ligase 3L
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Cytosol Membrane Early Endosome Membrane Protein-containing Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Histone Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity STAT Family Protein Binding Protein ADP-ribosyltransferase-substrate Adaptor Activity Histone Ubiquitin Ligase Activity Histone H4K91 Ubiquitin Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	DNA Damage Checkpoint Signaling Positive Regulation Of Defense Response To Virus By Host Immune System Process DNA Repair Double-strand Break Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Notch Signaling Pathway Endosome To Lysosome Transport Protein Transport Protein Ubiquitination Positive Regulation Of Protein Binding Positive Regulation Of Chromatin Binding Innate Immune Response Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ubiquitin-protein Transferase Activity Defense Response To Virus Protein Autoubiquitination Protein K48-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Receptor Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 22472876)
Interacting Genes		111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	22 interacting genes: ANTXR1 DTX1 H2AC4 H2AZ2 ITCH PARP9 PHF7 RNF111 SPG21 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2R2 UBE2W
Entrez ID		51619	151636
HPRD ID		14242	16843
Ensembl ID		ENSG00000078967	ENSG00000163840
Uniprot IDs		Q9Y2X8	Q8TDB6
PDB IDs			3PG6 8R79
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Ubiquitin-protein Transferase Activity Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Protein Metabolic Process ATP Binding Catabolic Process Ubiquitin Protein Ligase Activity Nucleotide Binding Macromolecule Metabolic Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Nucleus Proteasomal Protein Catabolic Process ISG15-protein Conjugation Protein Catabolic Process Protein Autoubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Macromolecule Biosynthetic Process Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Cytosol Endosome Membrane Protein K6-linked Ubiquitination Ubiquitin-like Protein Ligase Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process SUMO Conjugating Enzyme Activity NAD+-protein-C-terminal Glycine ADP-ribosyltransferase Activity Nucleoplasm Regulation Of Signal Transduction Protein-containing Complex Global Genome Nucleotide-excision Repair ADP-D-ribose Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?