MIB1 and JAG1

Number of citations of the paper that reports this interaction (PubMedID 25747658)
43

Data Source:
BioGRID (enzymatic study)

		MIB1	JAG1
Description		MIB E3 ubiquitin protein ligase 1	jagged canonical Notch ligand 1
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse	Extracellular Region Plasma Membrane Adherens Junction Membrane Apical Plasma Membrane Apical Part Of Cell
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Notch Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Growth Factor Activity Molecular Adaptor Activity
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Angiogenesis Cell Fate Determination Negative Regulation Of Cell-matrix Adhesion Blood Vessel Remodeling Morphogenesis Of An Epithelial Sheet Inhibition Of Neuroepithelial Cell Differentiation T Cell Mediated Immunity Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Cardiac Right Ventricle Morphogenesis Cell Communication Notch Signaling Pathway Nervous System Development Animal Organ Morphogenesis Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell-cell Adhesion Hemopoiesis Neuron Differentiation Keratinocyte Differentiation Negative Regulation Of Cell Migration Response To Muramyl Dipeptide Aorta Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Auditory Receptor Cell Differentiation Camera-type Eye Development Myoblast Differentiation Endothelial Cell Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development System Development Inner Ear Development Regulation Of Epithelial Cell Proliferation Cardiac Septum Morphogenesis Ciliary Body Morphogenesis Neuroendocrine Cell Differentiation Pulmonary Artery Morphogenesis Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Endocardial Cushion Cell Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Nephron Development Podocyte Development Distal Tubule Development Loop Of Henle Development Neuronal Stem Cell Population Maintenance Negative Regulation Of Stem Cell Differentiation
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus RUNX3 regulates NOTCH signaling RAC1 GTPase cycle RAC3 GTPase cycle NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Nephron development
Drugs
Diseases			Tetralogy of Fallot Alagille syndrome
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)	Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Bone mineral density ( 20096396) Bone mineral density (spine) ( 30172743) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Diastolic blood pressure ( 21909115 27618447 27618452 26390057 27841878 25249183 28135244 28739976) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Eosinophil count ( 32888494) Frontotemporal dementia (age at onset) ( 29724592) Frontotemporal dementia with GRN mutation (age at onset) ( 29724592) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lumbar spine bone mineral density ( 22504420 29499414) Lymphocyte count ( 32888494) Migraine ( 27322543) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Red blood cell count ( 32888494) Systolic blood pressure ( 28739976 28135244 27841878 25249183 27618452 21909115) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Type 2 diabetes ( 28828242) Urate levels ( 31578528) Urinary bladder cancer ( 24861552)
Interacting Genes		17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN	9 interacting genes: AFDN MFNG MIB1 MTDH NOTCH1 NOTCH2 NOTCH3 POFUT1 THBS1
Entrez ID		57534	182
HPRD ID		06660	03562
Ensembl ID		ENSG00000101752	ENSG00000101384
Uniprot IDs		Q86YT6	P78504 Q99740
PDB IDs		4TSE 4XI6 4XI7 4XIB 8V0D 8V0E	2KB9 2VJ2 4CBZ 4CC0 4CC1 4XI7 5BO1
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination	Notch Signaling Pathway Anatomical Structure Formation Involved In Morphogenesis Tube Morphogenesis Angiogenesis Cellular Response To Tumor Cell Pattern Specification Process Negative Regulation Of Endothelial Cell Chemotaxis Atrioventricular Node Development Glomerular Capillary Formation Heart Looping Embryonic Heart Tube Morphogenesis Negative Regulation Of Neuron Differentiation Marginal Zone B Cell Differentiation Regulation Of Notch Signaling Pathway Blood Vessel Morphogenesis Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Left/right Axis Specification Epithelial Tube Morphogenesis Pulmonary Valve Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Epithelial Cell Development Morphogenesis Of An Epithelial Sheet Nephron Tubule Development Positive Regulation Of Smooth Muscle Cell Differentiation Renal Tubule Development Anterior/posterior Pattern Specification Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Mature B Cell Differentiation Involved In Immune Response Regulation Of Neuron Differentiation NF-kappaB Binding Mature B Cell Differentiation Receptor Complex Inflammatory Response To Antigenic Stimulus Sprouting Angiogenesis Positive Regulation Of BMP Signaling Pathway Neuron Fate Commitment Neuron Projection Guidance Axon Guidance Positive Regulation Of Notch Signaling Pathway Calcium Ion Binding Golgi Membrane Regulation Of Smooth Muscle Cell Differentiation In Utero Embryonic Development Cell Surface Receptor Signaling Pathway Regulation Of Ras Protein Signal Transduction Somitogenesis Chordate Embryonic Development Cell Surface Negative Regulation Of Chemotaxis Signal Transduction
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