UBE2D4 and TRIM38

Number of citations of the paper that reports this interaction (PubMedID 21143188)
0

Data Source:
BioGRID (two hybrid)

		UBE2D4	TRIM38
Description		ubiquitin conjugating enzyme E2 D4	tripartite motif containing 38
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Immune System Process Regulation Of Gene Expression Protein Ubiquitination Protein Sumoylation Regulation Of Interferon-beta Production Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Process Negative Regulation Of Defense Response To Virus Protein K48-linked Ubiquitination Regulation Of Viral Life Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS			A body shape index ( 34021172) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cardiac hypertrophy ( 21348951) Fish- and plant-related diet ( 32066663) Height ( 28552196) Iron status biomarkers ( 19084217) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		111 interacting genes: AMFR ARIH2 ARK2C BFAR BIRC8 CADPS2 CHFR CNOT4 DAZAP2 DTX1 DTX2 DTX3 DTX3L DZIP3 IKBKG INCA1 ITCH LNX1 LRSAM1 MAGEA11 MAP3K1 MARCHF3 MDM2 MGRN1 MIB1 MID1 MID2 MKRN1 MKRN2 MKRN3 MUL1 MYBL2 MYLIP OTUB1 PHF7 PJA2 POLR2E PRKN RBCK1 RBX1 RCHY1 REL RFWD3 RING1 RLIM RMND5B RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF13 RNF130 RNF138 RNF14 RNF150 RNF166 RNF167 RNF181 RNF185 RNF2 RNF216 RNF25 RNF26 RNF31 RNF38 RNF4 RNF43 RNF5 RNF7 SIAH1 STUB1 TOPORS TRAF6 TRAF7 TRIM10 TRIM17 TRIM2 TRIM23 TRIM25 TRIM27 TRIM3 TRIM31 TRIM35 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM62 TRIM8 UBA1 UBA6 UBC UBE4A UBOX5 UBR5 UBTD1 UBTD2 UFM1 UHRF2 UVSSA WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	30 interacting genes: ATXN1 BYSL EIF1B GMCL1 GORASP2 HSPA1A HSPA1B HSPA1L HSPA2 HSPA8 MTURN PIAS4 PSMA4 RFC5 RIPK1 RNF4 SDCBP STXBP1 TCEA2 TSPYL4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2U ZNF764
Entrez ID		51619	10475
HPRD ID		14242	15555
Ensembl ID		ENSG00000078967	ENSG00000112343
Uniprot IDs		Q9Y2X8	O00635
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Zinc Ion Binding Protein Polyubiquitination Transferase Activity Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Proteolysis Involved In Protein Catabolic Process Metal Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Ubiquitin-ubiquitin Ligase Activity Innate Immune Response Response To Stress Defense Response To Symbiont Response To Other Organism Defense Response To Other Organism Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Protein K29-linked Ubiquitination Regulation Of Signal Transduction Response To External Biotic Stimulus Immune System Process Defense Response Suppression Of Viral Release By Host Regulation Of Intracellular Signal Transduction Immune Response Protein Monoubiquitination Regulation Of Defense Response Cellular Response To Stress Positive Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Canonical NF-kappaB Signal Transduction Protein Destabilization Host-mediated Suppression Of Symbiont Invasion	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination ATP Binding Protein Refolding Protein Polyubiquitination ATP-dependent Protein Folding Chaperone Protein K11-linked Ubiquitination Ubiquitin-protein Transferase Activity Nucleotide Binding Macromolecule Catabolic Process Protein Modification By Small Protein Conjugation C3HC4-type RING Finger Domain Binding Protein Folding Chaperone Blood Microparticle ATP-dependent Protein Disaggregase Activity Heat Shock Protein Binding Post-translational Protein Modification Response To Unfolded Protein Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Inclusion Body Assembly Protein Ubiquitination Unfolded Protein Binding Nucleus Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Monoubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification Process Nucleoplasm Regulation Of Inclusion Body Assembly Macromolecule Metabolic Process Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Transferase Activity Protein K63-linked Ubiquitination Protein K6-linked Ubiquitination Cellular Response To Steroid Hormone Stimulus ISG15 Transferase Activity Ubiquitin Protein Ligase Binding Cellular Response To Stress Regulation Of Spindle Assembly Catabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Metabolic Process Protein Folding Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Protein Localization To Chromatin ISG15-protein Conjugation Positive Regulation Of Myeloid Cell Differentiation ATP Hydrolysis Activity
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