MIB1 and AZI2

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (pull down)

		MIB1	AZI2
Description		MIB E3 ubiquitin protein ligase 1	5-azacytidine induced 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Cytoplasmic Vesicle Centriolar Satellite Glutamatergic Synapse	Cytoplasm Serine/threonine Protein Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Heart Development Protein Ubiquitination Central Nervous System Neuron Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis	Mitotic Cell Cycle T Cell Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Dendritic Cell Proliferation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Dendritic Cell Differentiation
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Severe progression in rheumatoid arthritis ( 29065906)	Cognitive decline (age-related) ( 28078323)
Interacting Genes		17 interacting genes: AZI2 BLM DAB2 DAPK1 EPB41L4A GABARAP JAG1 RIPK4 SNX5 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W WRN	16 interacting genes: APBA3 FAM107A GABARAP GABARAPL1 GABARAPL2 IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA
Entrez ID		57534	64343
HPRD ID		06660	10577
Ensembl ID		ENSG00000101752	ENSG00000163512
Uniprot IDs		Q86YT6	Q9H6S1
PDB IDs		4TSE 4XI6 4XI7 4XIB 8V0D 8V0E	5EP6 5Z7G 5Z7L 7EA2 7EA7
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination ATP Binding Ubiquitin-protein Transferase Activity Nucleotide Binding Forked DNA-dependent Helicase Activity Positive Regulation Of Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Protein Ubiquitination Regulation Of Protein Polyubiquitination Telomeric D-loop Binding Y-form DNA Binding Transferase Activity Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Response To Nutrient Levels Macromolecule Catabolic Process Protein K11-linked Ubiquitination DNA Repair Four-way Junction Helicase Activity Catabolic Process Telomere Maintenance Via Semi-conservative Replication Post-translational Protein Modification DNA Geometric Change Bubble DNA Binding Protein Monoubiquitination Telomeric D-loop Disassembly G-quadruplex DNA Binding Protein Catabolic Process TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Telomeric Loop Disassembly T-circle Formation 3'-5' DNA Helicase Activity TOR Signaling DNA Metabolic Process Negative Regulation Of TOR Signaling Four-way Junction DNA Binding Proteasomal Protein Catabolic Process DNA Conformation Change Response To Nutrient Levels Regulation Of TORC1 Signaling DNA Damage Response Cellular Response To Stress Positive Regulation Of Protein Ubiquitination	Autophagosome Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Autophagy Autophagosome Membrane Macroautophagy Phosphatidylethanolamine Binding GABA Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cytoplasm Autophagy Of Mitochondrion Serine/threonine Protein Kinase Complex Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Activation Of Immune Response Autophagosome Assembly Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Autophagosome Organization Response To Other Organism Cellular Response To Nutrient Levels Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Defense Response To Virus Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Beta-tubulin Binding Response To External Biotic Stimulus Defense Response Regulation Of Immune Response Immune System Process Response To Stress Immune Response-activating Signaling Pathway Autophagosome Maturation Pattern Recognition Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Innate Immune Response Vacuole Organization Positive Regulation Of Autophagy Positive Regulation Of Immune Response Innate Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Mitophagy Regulation Of Interferon-beta Production Response To Virus
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