RPTOR and IRS1

  • Number of citations of the paper that reports this interaction (PMID 16354680)
  • 93
  • Data Source:
  • BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)
  • HPRD (in vitro)

RPTOR

IRS1

Gene Name regulatory associated protein of MTOR, complex 1 insulin receptor substrate 1
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 20 interactors: AKT1S1 EIF4EBP1 ICK IRS1 IRS2 MAPK1 MAPK3 MARK4 MLST8 MTOR PLD2 PRKAA1 PRKAA2 PRR5L RAP1B RHEB RPS6KA1 RPS6KB1 RRAGA RRAGB 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 57521 3667
HPRD ID 06184 00943
Ensembl ID ENSG00000141564 ENSG00000169047
Uniprot IDs F5H7J5 Q6DKI0 Q8N122 P35568
PDB IDs 1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
ablation  balanced  cns  complexes  contributions  delicately  functionally  hypomyelination  integrates  lipogenesis  lipogenic  minor  mtor  mtorc1  mtorc2  myelin  myelination  oligodendrocyte  oligodendrocytes  overactivation  overtones  practical  rapamycin  reliant  rictor  sclerosis  tsc1  tuberous 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Difference) ?
ablation  balanced  cns  complexes  contributions  delicately  functionally  hypomyelination  integrates  lipogenesis  lipogenic  minor  mtor  mtorc1  mtorc2  myelin  myelination  oligodendrocyte  oligodendrocytes  overactivation  overtones  practical  rapamycin  reliant  rictor  sclerosis  tsc1  tuberous 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Intersection) ?